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Relation of habitual diet and cardiorespiratory fitness to blood coagulation and fibrinolytic factors.
Thromb Haemost. 1994 Feb; 71(2):180-3.TH

Abstract

The relation of habitual diet and cardiorespiratory fitness to plasma fibrinogen concentration, Factor VII activity (F VIIc), Factor X activity (F X), tissue plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1) concentrations, anti-thrombin III (AT III) and apolipoprotein(a) (Apo[a]) was analyzed in 111 normolipidemic men aged 51-53 years. Diet was evaluated by seven day food records. Maximal oxygen consumption and aerobic threshold were determined in maximal bicycle ergospirometry test based on breath-by-breath analysis of expired respiratory gas. Plasma fibrinogen was measured by thrombin method, F VIIc by one-stage coagulation method, AT III and F X colorimetrically, t-PA and PAI-1 antigens by ELISA and Apo(a) concentration radioimmunologically. Carbohydrate intake was negatively (r = -0.31, p < 0.001; r = -0.24, p < 0.01; r = -0.36, p < 0.001) and fat intake positively (r = 0.24, p < 0.01; r = 0.29, p < 0.001; r = 0.32, p < 0.001) related to F X, PAI-1, and t-PA, respectively. Aerobic threshold correlated negatively with fibrinogen (r = -0.33, p < 0.001) and F X (r = -0.30, p < 0.001). Fasting insulin was the strongest determinant for PAI-1 (r = 0.55, p < 0.001) and a significant positive correlate to F VIIc (r = 0.30, p < 0.001), F X (r = 0.28, p < 0.01) and t-PA (r = 0.47, p < 0.001). These data emphasize the importance that carbohydrate rich diet and cardiorespiratory fitness may have against thrombogenesis.

Authors+Show Affiliations

Kuopio Research Institute of Exercise Medicine, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8191395

Citation

Rankinen, T, et al. "Relation of Habitual Diet and Cardiorespiratory Fitness to Blood Coagulation and Fibrinolytic Factors." Thrombosis and Haemostasis, vol. 71, no. 2, 1994, pp. 180-3.
Rankinen T, Rauramaa R, Väisänen S, et al. Relation of habitual diet and cardiorespiratory fitness to blood coagulation and fibrinolytic factors. Thromb Haemost. 1994;71(2):180-3.
Rankinen, T., Rauramaa, R., Väisänen, S., Penttilä, I. M., & Uusitupa, M. (1994). Relation of habitual diet and cardiorespiratory fitness to blood coagulation and fibrinolytic factors. Thrombosis and Haemostasis, 71(2), 180-3.
Rankinen T, et al. Relation of Habitual Diet and Cardiorespiratory Fitness to Blood Coagulation and Fibrinolytic Factors. Thromb Haemost. 1994;71(2):180-3. PubMed PMID: 8191395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation of habitual diet and cardiorespiratory fitness to blood coagulation and fibrinolytic factors. AU - Rankinen,T, AU - Rauramaa,R, AU - Väisänen,S, AU - Penttilä,I M, AU - Uusitupa,M, PY - 1994/2/1/pubmed PY - 1994/2/1/medline PY - 1994/2/1/entrez SP - 180 EP - 3 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 71 IS - 2 N2 - The relation of habitual diet and cardiorespiratory fitness to plasma fibrinogen concentration, Factor VII activity (F VIIc), Factor X activity (F X), tissue plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1) concentrations, anti-thrombin III (AT III) and apolipoprotein(a) (Apo[a]) was analyzed in 111 normolipidemic men aged 51-53 years. Diet was evaluated by seven day food records. Maximal oxygen consumption and aerobic threshold were determined in maximal bicycle ergospirometry test based on breath-by-breath analysis of expired respiratory gas. Plasma fibrinogen was measured by thrombin method, F VIIc by one-stage coagulation method, AT III and F X colorimetrically, t-PA and PAI-1 antigens by ELISA and Apo(a) concentration radioimmunologically. Carbohydrate intake was negatively (r = -0.31, p < 0.001; r = -0.24, p < 0.01; r = -0.36, p < 0.001) and fat intake positively (r = 0.24, p < 0.01; r = 0.29, p < 0.001; r = 0.32, p < 0.001) related to F X, PAI-1, and t-PA, respectively. Aerobic threshold correlated negatively with fibrinogen (r = -0.33, p < 0.001) and F X (r = -0.30, p < 0.001). Fasting insulin was the strongest determinant for PAI-1 (r = 0.55, p < 0.001) and a significant positive correlate to F VIIc (r = 0.30, p < 0.001), F X (r = 0.28, p < 0.01) and t-PA (r = 0.47, p < 0.001). These data emphasize the importance that carbohydrate rich diet and cardiorespiratory fitness may have against thrombogenesis. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/8191395/Relation_of_habitual_diet_and_cardiorespiratory_fitness_to_blood_coagulation_and_fibrinolytic_factors_ L2 - https://medlineplus.gov/exerciseandphysicalfitness.html DB - PRIME DP - Unbound Medicine ER -