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[Prokinetics in reflux disease. Action mechanisms and clinical effects].
Tidsskr Nor Laegeforen 1994; 114(6):689-92TN

Abstract

Gastro-oesophageal reflux disease is a primary motility disorder of the upper gastro-intestinal tract, with varying degrees of disturbed lower oesophageal sphincter function, disturbed peristalsis of the oesophageal body and delayed gastric emptying. Traditional treatment has focused on "detoxifying" the refluxate by suppressing gastric acid secretion. With the advent of cisapride (Prepulsid), prokinetic drugs offer a possibility of influencing the underlying motility disturbances without causing the serious side effects of earlier prokinetic drugs. It seems to be well documented that cisapride is useful in both the short-term and the long-term treatment of grade 1 reflux oesophagitis, and also in more severe cases as part of combination regimens involving acid suppressive drugs.

Authors+Show Affiliations

Gastroenterologisk seksjon, Haukeland Sykehus, Bergen.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

nor

PubMed ID

8191452

Citation

Hatlebakk, J G., and A Berstad. "[Prokinetics in Reflux Disease. Action Mechanisms and Clinical Effects]." Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, vol. 114, no. 6, 1994, pp. 689-92.
Hatlebakk JG, Berstad A. [Prokinetics in reflux disease. Action mechanisms and clinical effects]. Tidsskr Nor Laegeforen. 1994;114(6):689-92.
Hatlebakk, J. G., & Berstad, A. (1994). [Prokinetics in reflux disease. Action mechanisms and clinical effects]. Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, 114(6), pp. 689-92.
Hatlebakk JG, Berstad A. [Prokinetics in Reflux Disease. Action Mechanisms and Clinical Effects]. Tidsskr Nor Laegeforen. 1994 Feb 28;114(6):689-92. PubMed PMID: 8191452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Prokinetics in reflux disease. Action mechanisms and clinical effects]. AU - Hatlebakk,J G, AU - Berstad,A, PY - 1994/2/28/pubmed PY - 1994/2/28/medline PY - 1994/2/28/entrez SP - 689 EP - 92 JF - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke JO - Tidsskr. Nor. Laegeforen. VL - 114 IS - 6 N2 - Gastro-oesophageal reflux disease is a primary motility disorder of the upper gastro-intestinal tract, with varying degrees of disturbed lower oesophageal sphincter function, disturbed peristalsis of the oesophageal body and delayed gastric emptying. Traditional treatment has focused on "detoxifying" the refluxate by suppressing gastric acid secretion. With the advent of cisapride (Prepulsid), prokinetic drugs offer a possibility of influencing the underlying motility disturbances without causing the serious side effects of earlier prokinetic drugs. It seems to be well documented that cisapride is useful in both the short-term and the long-term treatment of grade 1 reflux oesophagitis, and also in more severe cases as part of combination regimens involving acid suppressive drugs. SN - 0029-2001 UR - https://www.unboundmedicine.com/medline/citation/8191452/[Prokinetics_in_reflux_disease__Action_mechanisms_and_clinical_effects]_ L2 - https://medlineplus.gov/gerd.html DB - PRIME DP - Unbound Medicine ER -