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[Coenzyme Q10 (ubiquinone) in the treatment of heart failure. Are any positive effects documented?].
Tidsskr Nor Laegeforen 1994; 114(8):939-42TN

Abstract

Coenzyme Q10 is an endogenous substance which has a well established role as electron carrier in the mitochondrial synthesis of adenosine triphosphate (ATP). In addition, coenzyme Q10 also has antioxidant and membrane stabilizing properties. Based on biopsy samples from patients undergoing cardiac surgery and blood samples from patients with congestive heart failure, the existence of a relative Q10 deficiency in patients with cardiac failure has been suggested. A total number of eight double blind, placebo controlled studies in patients with heart failure have been published. Most of these studies include a small number of patients, and various methodological problems have been attributed to these. The results, judged as improvement in ejection fraction or work capacity, are inconsistent. In one large study, coenzyme Q10 was found to have a positive effect on morbidity, and in another on quality of life. However, although some of the results appear to be promising, more studies are needed, including studies designed with mortality as a primary end point, before the effect of the substance in patients with heart failure can be established.

Authors+Show Affiliations

Avdelningen för klinisk farmakologi, Norrlands Universitetssjukhus, Umeå.

Pub Type(s)

English Abstract
Journal Article
Review

Language

nor

PubMed ID

8191473

Citation

Spigset, O. "[Coenzyme Q10 (ubiquinone) in the Treatment of Heart Failure. Are Any Positive Effects Documented?]." Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, vol. 114, no. 8, 1994, pp. 939-42.
Spigset O. [Coenzyme Q10 (ubiquinone) in the treatment of heart failure. Are any positive effects documented?]. Tidsskr Nor Laegeforen. 1994;114(8):939-42.
Spigset, O. (1994). [Coenzyme Q10 (ubiquinone) in the treatment of heart failure. Are any positive effects documented?]. Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, 114(8), pp. 939-42.
Spigset O. [Coenzyme Q10 (ubiquinone) in the Treatment of Heart Failure. Are Any Positive Effects Documented?]. Tidsskr Nor Laegeforen. 1994 Mar 20;114(8):939-42. PubMed PMID: 8191473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Coenzyme Q10 (ubiquinone) in the treatment of heart failure. Are any positive effects documented?]. A1 - Spigset,O, PY - 1994/3/20/pubmed PY - 1994/3/20/medline PY - 1994/3/20/entrez SP - 939 EP - 42 JF - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke JO - Tidsskr. Nor. Laegeforen. VL - 114 IS - 8 N2 - Coenzyme Q10 is an endogenous substance which has a well established role as electron carrier in the mitochondrial synthesis of adenosine triphosphate (ATP). In addition, coenzyme Q10 also has antioxidant and membrane stabilizing properties. Based on biopsy samples from patients undergoing cardiac surgery and blood samples from patients with congestive heart failure, the existence of a relative Q10 deficiency in patients with cardiac failure has been suggested. A total number of eight double blind, placebo controlled studies in patients with heart failure have been published. Most of these studies include a small number of patients, and various methodological problems have been attributed to these. The results, judged as improvement in ejection fraction or work capacity, are inconsistent. In one large study, coenzyme Q10 was found to have a positive effect on morbidity, and in another on quality of life. However, although some of the results appear to be promising, more studies are needed, including studies designed with mortality as a primary end point, before the effect of the substance in patients with heart failure can be established. SN - 0029-2001 UR - https://www.unboundmedicine.com/medline/citation/8191473/[Coenzyme_Q10__ubiquinone__in_the_treatment_of_heart_failure__Are_any_positive_effects_documented]_ L2 - https://medlineplus.gov/heartfailure.html DB - PRIME DP - Unbound Medicine ER -