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Allopurinol mouthwashes in the treatment of 5-fluorouracil-induced stomatitis.
Am J Clin Oncol. 1994 Jun; 17(3):246-7.AJ

Abstract

This study was aimed at assessing the efficacy of allopurinol mouthwashes in the treatment of 5-fluorouracil-induced stomatitis. A randomized double-blind, placebo-controlled trial was thus designed to test its efficacy to treat oral mucositis in advanced cancer patients receiving 5-fluorouracil-containing chemotherapy. There were 44 patients randomized to receive allopurinol mouthwashes, or placebo, as soon as mucosal lesions were observed during any treatment cycle. Stomatitis was evaluated at the end of each 5-day treatment cycle. Allopurinol mouthwashes resolved stomatitis in 9 of 22 treated patients (40.9%), and diminished its intensity in 10 more patients (45.4%); stomatitis resolved completely in none of the 22 patients, and partially in 3 patients in the placebo group (p < .001 by chi 2 test). Duration of symptoms was also significantly different between the two groups (median: 4 days for the allopurinol group, 7.5 days for the control group; p < .0005 by Student's t-test). In conclusion, our results suggest that allopurinol mouthwashes can be effective to treat 5-fluorouracil-induced stomatitis.

Authors+Show Affiliations

Istituto di Terapia Medica, IRCCS Policlinico San Mateo, Università di Pavia, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8192112

Citation

Porta, C, et al. "Allopurinol Mouthwashes in the Treatment of 5-fluorouracil-induced Stomatitis." American Journal of Clinical Oncology, vol. 17, no. 3, 1994, pp. 246-7.
Porta C, Moroni M, Nastasi G. Allopurinol mouthwashes in the treatment of 5-fluorouracil-induced stomatitis. Am J Clin Oncol. 1994;17(3):246-7.
Porta, C., Moroni, M., & Nastasi, G. (1994). Allopurinol mouthwashes in the treatment of 5-fluorouracil-induced stomatitis. American Journal of Clinical Oncology, 17(3), 246-7.
Porta C, Moroni M, Nastasi G. Allopurinol Mouthwashes in the Treatment of 5-fluorouracil-induced Stomatitis. Am J Clin Oncol. 1994;17(3):246-7. PubMed PMID: 8192112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Allopurinol mouthwashes in the treatment of 5-fluorouracil-induced stomatitis. AU - Porta,C, AU - Moroni,M, AU - Nastasi,G, PY - 1994/6/1/pubmed PY - 1994/6/1/medline PY - 1994/6/1/entrez SP - 246 EP - 7 JF - American journal of clinical oncology JO - Am J Clin Oncol VL - 17 IS - 3 N2 - This study was aimed at assessing the efficacy of allopurinol mouthwashes in the treatment of 5-fluorouracil-induced stomatitis. A randomized double-blind, placebo-controlled trial was thus designed to test its efficacy to treat oral mucositis in advanced cancer patients receiving 5-fluorouracil-containing chemotherapy. There were 44 patients randomized to receive allopurinol mouthwashes, or placebo, as soon as mucosal lesions were observed during any treatment cycle. Stomatitis was evaluated at the end of each 5-day treatment cycle. Allopurinol mouthwashes resolved stomatitis in 9 of 22 treated patients (40.9%), and diminished its intensity in 10 more patients (45.4%); stomatitis resolved completely in none of the 22 patients, and partially in 3 patients in the placebo group (p < .001 by chi 2 test). Duration of symptoms was also significantly different between the two groups (median: 4 days for the allopurinol group, 7.5 days for the control group; p < .0005 by Student's t-test). In conclusion, our results suggest that allopurinol mouthwashes can be effective to treat 5-fluorouracil-induced stomatitis. SN - 0277-3732 UR - https://www.unboundmedicine.com/medline/citation/8192112/Allopurinol_mouthwashes_in_the_treatment_of_5_fluorouracil_induced_stomatitis_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=8192112.ui DB - PRIME DP - Unbound Medicine ER -