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Can 99Tcm HMPAO leucocyte scintigraphy distinguish between Crohn's disease and ulcerative colitis?
Br J Radiol. 1994 May; 67(797):472-7.BJ

Abstract

This paper has retrospectively analysed the ability of 99Tcm HMPAO leucocyte scintigraphy to distinguish Crohn's disease from ulcerative colitis. The diagnostic criteria were established by reviewing 99Tcm HMPAO leucocyte scintigrams in 123 patients with histologically proven Crohn's disease (83) or ulcerative colitis (40). Uptake in the right iliac fossa with or without other segments of colon, irregular bowel uptake, small bowel uptake or colonic activity with rectal sparing were all strongly suggestive of Crohn's disease. Left sided colitis was found to indicate ulcerative colitis. Total colitis occurred in both ulcerative colitis and Crohn's disease. The criteria were later tested in an additional 62 patients with excellent results (accuracy 98%). In 63 patients in whom the results of barium radiology were also available, the accuracy of scintigraphy was higher (93% and 83%, respectively). We conclude that 99Tcm HMPAO leucocyte scintigraphy can accurately distinguish between Crohn's disease and ulcerative colitis in a large proportion of cases and appears to be more reliable than conventional radiology.

Authors+Show Affiliations

Department of Nuclear Medicine, Addenbrooke's Hospital, Cambridge, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8193894

Citation

Li, D J., et al. "Can 99Tcm HMPAO Leucocyte Scintigraphy Distinguish Between Crohn's Disease and Ulcerative Colitis?" The British Journal of Radiology, vol. 67, no. 797, 1994, pp. 472-7.
Li DJ, Freeman A, Miles KA, et al. Can 99Tcm HMPAO leucocyte scintigraphy distinguish between Crohn's disease and ulcerative colitis? Br J Radiol. 1994;67(797):472-7.
Li, D. J., Freeman, A., Miles, K. A., & Wraight, E. P. (1994). Can 99Tcm HMPAO leucocyte scintigraphy distinguish between Crohn's disease and ulcerative colitis? The British Journal of Radiology, 67(797), 472-7.
Li DJ, et al. Can 99Tcm HMPAO Leucocyte Scintigraphy Distinguish Between Crohn's Disease and Ulcerative Colitis. Br J Radiol. 1994;67(797):472-7. PubMed PMID: 8193894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can 99Tcm HMPAO leucocyte scintigraphy distinguish between Crohn's disease and ulcerative colitis? AU - Li,D J, AU - Freeman,A, AU - Miles,K A, AU - Wraight,E P, PY - 1994/5/1/pubmed PY - 1994/5/1/medline PY - 1994/5/1/entrez SP - 472 EP - 7 JF - The British journal of radiology JO - Br J Radiol VL - 67 IS - 797 N2 - This paper has retrospectively analysed the ability of 99Tcm HMPAO leucocyte scintigraphy to distinguish Crohn's disease from ulcerative colitis. The diagnostic criteria were established by reviewing 99Tcm HMPAO leucocyte scintigrams in 123 patients with histologically proven Crohn's disease (83) or ulcerative colitis (40). Uptake in the right iliac fossa with or without other segments of colon, irregular bowel uptake, small bowel uptake or colonic activity with rectal sparing were all strongly suggestive of Crohn's disease. Left sided colitis was found to indicate ulcerative colitis. Total colitis occurred in both ulcerative colitis and Crohn's disease. The criteria were later tested in an additional 62 patients with excellent results (accuracy 98%). In 63 patients in whom the results of barium radiology were also available, the accuracy of scintigraphy was higher (93% and 83%, respectively). We conclude that 99Tcm HMPAO leucocyte scintigraphy can accurately distinguish between Crohn's disease and ulcerative colitis in a large proportion of cases and appears to be more reliable than conventional radiology. SN - 0007-1285 UR - https://www.unboundmedicine.com/medline/citation/8193894/Can_99Tcm_HMPAO_leucocyte_scintigraphy_distinguish_between_Crohn's_disease_and_ulcerative_colitis L2 - https://www.birpublications.org/doi/10.1259/0007-1285-67-797-472?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -