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Alcohol consumption and colon and rectal cancer in postmenopausal women.
Int J Epidemiol 1994; 23(1):50-7IJ

Abstract

The associations between alcohol and colon and rectal cancers were examined in the Iowa Women's Health Study. In January 1986, 41 837 postmenopausal women, aged 55-69, completed a questionnaire including usual alcohol intake and other information. Through December 1990, 237 incident colon and 75 rectal cancer cases occurred. Mantel-Haenszel age-adjusted relative risks (RR) and 95% confidence intervals (CI) for consumers of < 4.0 and > or = 4.0 g of alcohol per day compared to abstainers were 1.07 (0.61-1.89) and 1.27 (0.72-2.24) (P for trend = 0.46) for rectal cancer. Alcohol intake was inversely associated with distal colon cancer (RR for < 4.0 and > or = 4.0 g of alcohol per day were 0.64 and 0.69 respectively, P for trend = 0.04), which was specific to wine; however, no association was observed with proximal colon cancer (P for trend = 0.94). This is the only report of an inverse association between alcohol and colon cancer in women. Because gut physiology and alcohol metabolism differ between men and women, more research on the association between alcohol and colon cancer in women only, is warranted.

Authors+Show Affiliations

Division of Epidemiology, University of Minnesota, School of Public Health, Minneapolis 55454-1015.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8194924

Citation

Gapstur, S M., et al. "Alcohol Consumption and Colon and Rectal Cancer in Postmenopausal Women." International Journal of Epidemiology, vol. 23, no. 1, 1994, pp. 50-7.
Gapstur SM, Potter JD, Folsom AR. Alcohol consumption and colon and rectal cancer in postmenopausal women. Int J Epidemiol. 1994;23(1):50-7.
Gapstur, S. M., Potter, J. D., & Folsom, A. R. (1994). Alcohol consumption and colon and rectal cancer in postmenopausal women. International Journal of Epidemiology, 23(1), pp. 50-7.
Gapstur SM, Potter JD, Folsom AR. Alcohol Consumption and Colon and Rectal Cancer in Postmenopausal Women. Int J Epidemiol. 1994;23(1):50-7. PubMed PMID: 8194924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and colon and rectal cancer in postmenopausal women. AU - Gapstur,S M, AU - Potter,J D, AU - Folsom,A R, PY - 1994/2/1/pubmed PY - 1994/2/1/medline PY - 1994/2/1/entrez SP - 50 EP - 7 JF - International journal of epidemiology JO - Int J Epidemiol VL - 23 IS - 1 N2 - The associations between alcohol and colon and rectal cancers were examined in the Iowa Women's Health Study. In January 1986, 41 837 postmenopausal women, aged 55-69, completed a questionnaire including usual alcohol intake and other information. Through December 1990, 237 incident colon and 75 rectal cancer cases occurred. Mantel-Haenszel age-adjusted relative risks (RR) and 95% confidence intervals (CI) for consumers of < 4.0 and > or = 4.0 g of alcohol per day compared to abstainers were 1.07 (0.61-1.89) and 1.27 (0.72-2.24) (P for trend = 0.46) for rectal cancer. Alcohol intake was inversely associated with distal colon cancer (RR for < 4.0 and > or = 4.0 g of alcohol per day were 0.64 and 0.69 respectively, P for trend = 0.04), which was specific to wine; however, no association was observed with proximal colon cancer (P for trend = 0.94). This is the only report of an inverse association between alcohol and colon cancer in women. Because gut physiology and alcohol metabolism differ between men and women, more research on the association between alcohol and colon cancer in women only, is warranted. SN - 0300-5771 UR - https://www.unboundmedicine.com/medline/citation/8194924/Alcohol_consumption_and_colon_and_rectal_cancer_in_postmenopausal_women_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/23.1.50 DB - PRIME DP - Unbound Medicine ER -