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Pancreatic cystic islet-cell tumors. Clinical and pathologic features in two cases with cyst fluid analysis.
Int J Pancreatol. 1994 Feb; 15(1):75-9.IJ

Abstract

Cystic islet-cell tumors are rare neoplasms that may be confused with more familiar cystic pancreatic lesions, such as pseudocysts, serous cystadenoma, and mucinous tumors. Analysis of aspirated cyst fluid for tumor markers (carcinoembryonic antigen [CEA], CA-125, and CA-15.3), enzymes (amylase and lipase), viscosity, and cytology has been proposed as an aid to preoperative differential diagnosis. These tests will distinguish mucinous from nonmucinous cysts and usually help in determining malignancy. However, cyst fluid parameters from rarer types of pancreatic cystic tumors have not been described. We report the clinical and pathologic features of two cystic islet-cell tumors including cyst fluid parameters in one of the cases. Two cases of cystic islet-cell tumors were identified by clinical history, histopathologic, and immunohistochemical techniques. Cyst fluid was aspirated intraoperatively from one case and analyzed for CEA, CA-125, CA 15.3, insulin, amylase, viscosity, and cytology. Cyst fluid analysis showed low values for CEA, CA-125, and CA-15.3, low viscosity, and variable amylase content. This spectrum of findings is similar to that of serous cystadenomas. Cyst fluid cytologic examination was positive for neuroendocrine-type epithelial cells and insulin levels were elevated, observations indicative of an islet-cell tumor. Analysis of fluid from cystic islet-cell tumors may aid in the preoperative differentiation of these tumors from more common pancreatic cystic lesions. These findings represent the first report of the characteristics of the fluid in these uncommon tumors.

Authors+Show Affiliations

Department of Pathology, Massachusetts General Hospital, Boston 02114.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

8195644

Citation

Weissmann, D, et al. "Pancreatic Cystic Islet-cell Tumors. Clinical and Pathologic Features in Two Cases With Cyst Fluid Analysis." International Journal of Pancreatology : Official Journal of the International Association of Pancreatology, vol. 15, no. 1, 1994, pp. 75-9.
Weissmann D, Lewandrowski K, Godine J, et al. Pancreatic cystic islet-cell tumors. Clinical and pathologic features in two cases with cyst fluid analysis. Int J Pancreatol. 1994;15(1):75-9.
Weissmann, D., Lewandrowski, K., Godine, J., Centeno, B., & Warshaw, A. (1994). Pancreatic cystic islet-cell tumors. Clinical and pathologic features in two cases with cyst fluid analysis. International Journal of Pancreatology : Official Journal of the International Association of Pancreatology, 15(1), 75-9.
Weissmann D, et al. Pancreatic Cystic Islet-cell Tumors. Clinical and Pathologic Features in Two Cases With Cyst Fluid Analysis. Int J Pancreatol. 1994;15(1):75-9. PubMed PMID: 8195644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic cystic islet-cell tumors. Clinical and pathologic features in two cases with cyst fluid analysis. AU - Weissmann,D, AU - Lewandrowski,K, AU - Godine,J, AU - Centeno,B, AU - Warshaw,A, PY - 1994/2/1/pubmed PY - 1994/2/1/medline PY - 1994/2/1/entrez SP - 75 EP - 9 JF - International journal of pancreatology : official journal of the International Association of Pancreatology JO - Int J Pancreatol VL - 15 IS - 1 N2 - Cystic islet-cell tumors are rare neoplasms that may be confused with more familiar cystic pancreatic lesions, such as pseudocysts, serous cystadenoma, and mucinous tumors. Analysis of aspirated cyst fluid for tumor markers (carcinoembryonic antigen [CEA], CA-125, and CA-15.3), enzymes (amylase and lipase), viscosity, and cytology has been proposed as an aid to preoperative differential diagnosis. These tests will distinguish mucinous from nonmucinous cysts and usually help in determining malignancy. However, cyst fluid parameters from rarer types of pancreatic cystic tumors have not been described. We report the clinical and pathologic features of two cystic islet-cell tumors including cyst fluid parameters in one of the cases. Two cases of cystic islet-cell tumors were identified by clinical history, histopathologic, and immunohistochemical techniques. Cyst fluid was aspirated intraoperatively from one case and analyzed for CEA, CA-125, CA 15.3, insulin, amylase, viscosity, and cytology. Cyst fluid analysis showed low values for CEA, CA-125, and CA-15.3, low viscosity, and variable amylase content. This spectrum of findings is similar to that of serous cystadenomas. Cyst fluid cytologic examination was positive for neuroendocrine-type epithelial cells and insulin levels were elevated, observations indicative of an islet-cell tumor. Analysis of fluid from cystic islet-cell tumors may aid in the preoperative differentiation of these tumors from more common pancreatic cystic lesions. These findings represent the first report of the characteristics of the fluid in these uncommon tumors. SN - 0169-4197 UR - https://www.unboundmedicine.com/medline/citation/8195644/Pancreatic_cystic_islet_cell_tumors__Clinical_and_pathologic_features_in_two_cases_with_cyst_fluid_analysis_ L2 - http://www.diseaseinfosearch.org/result/5554 DB - PRIME DP - Unbound Medicine ER -