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"Minimal change" multiple system atrophy.
Mov Disord. 1994 Mar; 9(2):161-6.MD

Abstract

We describe the pathological findings in two patients who developed atypical parkinsonism and autonomic failure, leading to a diagnosis of multiple system atrophy (MSA). Postmortem examination of the brain showed cell loss restricted to substantia nigra and locus coeruleus. However, glial cytoplasmic inclusions (GCIs) were present in both cases. We propose that GCIs are highly suggestive of a pathological diagnosis of MSA in the absence of detectable cell loss outside pigmented brain stem nuclei and that brains from cases of atypical parkinsonism should routinely be examined for their presence.

Authors+Show Affiliations

University Department of Clinical Neurology, Institute of Neurology, London, England.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8196676

Citation

Wenning, G K., et al. ""Minimal Change" Multiple System Atrophy." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 9, no. 2, 1994, pp. 161-6.
Wenning GK, Quinn N, Magalhăes M, et al. "Minimal change" multiple system atrophy. Mov Disord. 1994;9(2):161-6.
Wenning, G. K., Quinn, N., Magalhăes, M., Mathias, C., & Daniel, S. E. (1994). "Minimal change" multiple system atrophy. Movement Disorders : Official Journal of the Movement Disorder Society, 9(2), 161-6.
Wenning GK, et al. "Minimal Change" Multiple System Atrophy. Mov Disord. 1994;9(2):161-6. PubMed PMID: 8196676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - "Minimal change" multiple system atrophy. AU - Wenning,G K, AU - Quinn,N, AU - Magalhăes,M, AU - Mathias,C, AU - Daniel,S E, PY - 1994/3/1/pubmed PY - 1994/3/1/medline PY - 1994/3/1/entrez SP - 161 EP - 6 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 9 IS - 2 N2 - We describe the pathological findings in two patients who developed atypical parkinsonism and autonomic failure, leading to a diagnosis of multiple system atrophy (MSA). Postmortem examination of the brain showed cell loss restricted to substantia nigra and locus coeruleus. However, glial cytoplasmic inclusions (GCIs) were present in both cases. We propose that GCIs are highly suggestive of a pathological diagnosis of MSA in the absence of detectable cell loss outside pigmented brain stem nuclei and that brains from cases of atypical parkinsonism should routinely be examined for their presence. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/8196676/"Minimal_change"_multiple_system_atrophy_ L2 - https://doi.org/10.1002/mds.870090206 DB - PRIME DP - Unbound Medicine ER -