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Effects of dietary corn and olive oil versus coconut fat on biliary cholesterol secretion in rats.
Int J Vitam Nutr Res. 1994; 64(1):75-80.IJ

Abstract

We have studied the effects of dietary corn and olive oil versus coconut fat on bile formation and fluidity of hepatic plasma membranes in rats. After 4 weeks of feeding the purified diets containing 9% (w/w) of the test fats, there was no difference in plasma cholesterol concentration between the dietary groups. The amount of free and esterified cholesterol in the liver was significantly higher in rats fed either corn oil or olive oil as compared with coconut fat. In the rats fed olive oil, but not in those fed corn oil this was associated with lower rates of biliary phospholipid excretion. Bile flow was not differently influenced by the three dietary fats. Hepatic plasma membranes of the rats fed corn or olive oil contained more cholesterol and less phospholipids than those on coconut fat, which was, however, not accompanied by changes in fluidity of the membranes. These results indicate that in rats the type of dietary fat can induce considerable changes in hepatic cholesterol metabolism without affecting plasma cholesterol concentrations, and without consistent effects on biliary cholesterol secretion.

Authors+Show Affiliations

Department of Pediatrics, University of Groningen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8200753

Citation

Smit, M J., et al. "Effects of Dietary Corn and Olive Oil Versus Coconut Fat On Biliary Cholesterol Secretion in Rats." International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, vol. 64, no. 1, 1994, pp. 75-80.
Smit MJ, Wolters H, Temmerman AM, et al. Effects of dietary corn and olive oil versus coconut fat on biliary cholesterol secretion in rats. Int J Vitam Nutr Res. 1994;64(1):75-80.
Smit, M. J., Wolters, H., Temmerman, A. M., Kuipers, F., Beynen, A. C., & Vonk, R. J. (1994). Effects of dietary corn and olive oil versus coconut fat on biliary cholesterol secretion in rats. International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, 64(1), 75-80.
Smit MJ, et al. Effects of Dietary Corn and Olive Oil Versus Coconut Fat On Biliary Cholesterol Secretion in Rats. Int J Vitam Nutr Res. 1994;64(1):75-80. PubMed PMID: 8200753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary corn and olive oil versus coconut fat on biliary cholesterol secretion in rats. AU - Smit,M J, AU - Wolters,H, AU - Temmerman,A M, AU - Kuipers,F, AU - Beynen,A C, AU - Vonk,R J, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 75 EP - 80 JF - International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition JO - Int J Vitam Nutr Res VL - 64 IS - 1 N2 - We have studied the effects of dietary corn and olive oil versus coconut fat on bile formation and fluidity of hepatic plasma membranes in rats. After 4 weeks of feeding the purified diets containing 9% (w/w) of the test fats, there was no difference in plasma cholesterol concentration between the dietary groups. The amount of free and esterified cholesterol in the liver was significantly higher in rats fed either corn oil or olive oil as compared with coconut fat. In the rats fed olive oil, but not in those fed corn oil this was associated with lower rates of biliary phospholipid excretion. Bile flow was not differently influenced by the three dietary fats. Hepatic plasma membranes of the rats fed corn or olive oil contained more cholesterol and less phospholipids than those on coconut fat, which was, however, not accompanied by changes in fluidity of the membranes. These results indicate that in rats the type of dietary fat can induce considerable changes in hepatic cholesterol metabolism without affecting plasma cholesterol concentrations, and without consistent effects on biliary cholesterol secretion. SN - 0300-9831 UR - https://www.unboundmedicine.com/medline/citation/8200753/Effects_of_dietary_corn_and_olive_oil_versus_coconut_fat_on_biliary_cholesterol_secretion_in_rats_ L2 - https://medlineplus.gov/cholesterollevelswhatyouneedtoknow.html DB - PRIME DP - Unbound Medicine ER -