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Protective effects of Mikania cordata root extract against physical and chemical factors-induced gastric erosions in experimental animals.
Planta Med. 1994 Apr; 60(2):110-3.PM

Abstract

The effect of the methanolic fraction of Mikania cordata (Burm., B. L. Robinson) root extract was investigated for its possible ulceroprotective activity in male Sprague-Dawley rats. Oral administration of this extract (50, 100, or 150 mg/kg) significantly prevented the occurrence of water immersion stress-induced gastric ulcers in a dose-responsive manner. The extract also dose-dependently inhibited gastric ulcers induced by ethanol, aspirin, and phenylbutazone. The ED50 values of the extract in the above four ulcer models were found to be 95.1, 109.7, 125.5, and 136.2 mg/kg, respectively. The volume, acidity, and peptic activity of the gastric juice in pylorous-ligated rats were not altered upon administration of the extract (100 or 150 mg/kg) but it significantly and dose-dependently promoted the gastric mucus secretion in normal as well as stress- and ethanol-induced ulcerated animals. Based on these results, we conclude that M. cordata root extract possesses antiulcer activity and that the observed activity may be due to the modulation of defensive factors through an improvement of gastric cytoprotection.

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Authors+Show Affiliations

Bishayee A
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Chatterjee M
No affiliation info available

MeSH

AnimalsAnti-Ulcer AgentsIndiaMalePlant ExtractsPlants, MedicinalRatsRats, Sprague-DawleyStomach Ulcer

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8202558

Citation

Bishayee, A, and M Chatterjee. "Protective Effects of Mikania Cordata Root Extract Against Physical and Chemical Factors-induced Gastric Erosions in Experimental Animals." Planta Medica, vol. 60, no. 2, 1994, pp. 110-3.
Bishayee A, Chatterjee M. Protective effects of Mikania cordata root extract against physical and chemical factors-induced gastric erosions in experimental animals. Planta Med. 1994;60(2):110-3.
Bishayee, A., & Chatterjee, M. (1994). Protective effects of Mikania cordata root extract against physical and chemical factors-induced gastric erosions in experimental animals. Planta Medica, 60(2), 110-3.
Bishayee A, Chatterjee M. Protective Effects of Mikania Cordata Root Extract Against Physical and Chemical Factors-induced Gastric Erosions in Experimental Animals. Planta Med. 1994;60(2):110-3. PubMed PMID: 8202558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of Mikania cordata root extract against physical and chemical factors-induced gastric erosions in experimental animals. AU - Bishayee,A, AU - Chatterjee,M, PY - 1994/4/1/pubmed PY - 1994/4/1/medline PY - 1994/4/1/entrez SP - 110 EP - 3 JF - Planta medica JO - Planta Med VL - 60 IS - 2 N2 - The effect of the methanolic fraction of Mikania cordata (Burm., B. L. Robinson) root extract was investigated for its possible ulceroprotective activity in male Sprague-Dawley rats. Oral administration of this extract (50, 100, or 150 mg/kg) significantly prevented the occurrence of water immersion stress-induced gastric ulcers in a dose-responsive manner. The extract also dose-dependently inhibited gastric ulcers induced by ethanol, aspirin, and phenylbutazone. The ED50 values of the extract in the above four ulcer models were found to be 95.1, 109.7, 125.5, and 136.2 mg/kg, respectively. The volume, acidity, and peptic activity of the gastric juice in pylorous-ligated rats were not altered upon administration of the extract (100 or 150 mg/kg) but it significantly and dose-dependently promoted the gastric mucus secretion in normal as well as stress- and ethanol-induced ulcerated animals. Based on these results, we conclude that M. cordata root extract possesses antiulcer activity and that the observed activity may be due to the modulation of defensive factors through an improvement of gastric cytoprotection. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/8202558/Protective_effects_of_Mikania_cordata_root_extract_against_physical_and_chemical_factors_induced_gastric_erosions_in_experimental_animals_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2006-959428 DB - PRIME DP - Unbound Medicine ER -