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Controlled studies of Daflon 500 mg in chronic venous insufficiency.
Angiology. 1994 Jun; 45(6 Pt 2):549-53.A

Abstract

Although great advances have been made in the operative treatment of vascular disorders, the management of most venous problems is still nonsurgical. Daflon 500 mg* is a micronized flavonoid mixture of 90% diosmin and 10% hesperidin that has phlebotonic properties. The efficacy of Daflon 500 mg has been investigated in three double-blind, randomized trials using strain gauge plethysmography to provide quantitative information on venous hemodynamics in patients with chronic venous insufficiency. In total, 183 patients were treated with Daflon 500 mg versus a control group of equal number of patients. Daflon 500 mg produced a significant decrease in venous capacitance, venous distensibility, and venous emptying time (P < 0.001). In addition, these changes were accompanied by improvement in clinical symptoms and a decrease in the supramalleolar circumference. Clinical side effects were rare and led to treatment withdrawal in only 3 patients. It is concluded that Daflon 500 mg is of benefit to patients with chronic venous insufficiency.

Authors+Show Affiliations

Academic Surgical Unit, St. Mary's Hospital Medical School, Imperial College of Science Technology and Medicine, London, England.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8203786

Citation

Geroulakos, G, and A N. Nicolaides. "Controlled Studies of Daflon 500 Mg in Chronic Venous Insufficiency." Angiology, vol. 45, no. 6 Pt 2, 1994, pp. 549-53.
Geroulakos G, Nicolaides AN. Controlled studies of Daflon 500 mg in chronic venous insufficiency. Angiology. 1994;45(6 Pt 2):549-53.
Geroulakos, G., & Nicolaides, A. N. (1994). Controlled studies of Daflon 500 mg in chronic venous insufficiency. Angiology, 45(6 Pt 2), 549-53.
Geroulakos G, Nicolaides AN. Controlled Studies of Daflon 500 Mg in Chronic Venous Insufficiency. Angiology. 1994;45(6 Pt 2):549-53. PubMed PMID: 8203786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Controlled studies of Daflon 500 mg in chronic venous insufficiency. AU - Geroulakos,G, AU - Nicolaides,A N, PY - 1994/6/1/pubmed PY - 1994/6/1/medline PY - 1994/6/1/entrez SP - 549 EP - 53 JF - Angiology JO - Angiology VL - 45 IS - 6 Pt 2 N2 - Although great advances have been made in the operative treatment of vascular disorders, the management of most venous problems is still nonsurgical. Daflon 500 mg* is a micronized flavonoid mixture of 90% diosmin and 10% hesperidin that has phlebotonic properties. The efficacy of Daflon 500 mg has been investigated in three double-blind, randomized trials using strain gauge plethysmography to provide quantitative information on venous hemodynamics in patients with chronic venous insufficiency. In total, 183 patients were treated with Daflon 500 mg versus a control group of equal number of patients. Daflon 500 mg produced a significant decrease in venous capacitance, venous distensibility, and venous emptying time (P < 0.001). In addition, these changes were accompanied by improvement in clinical symptoms and a decrease in the supramalleolar circumference. Clinical side effects were rare and led to treatment withdrawal in only 3 patients. It is concluded that Daflon 500 mg is of benefit to patients with chronic venous insufficiency. SN - 0003-3197 UR - https://www.unboundmedicine.com/medline/citation/8203786/Controlled_studies_of_Daflon_500_mg_in_chronic_venous_insufficiency_ DB - PRIME DP - Unbound Medicine ER -