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Famotidine as an adjunct treatment of resistant schizophrenia.

Abstract

Some patients suffering from schizophrenia fail to respond to or tolerate adequate doses of available antipsychotic medications. Thus, innovative pharmacotherapeutic approaches, such as augmentation strategies, play an important role in the management of these treatment-resistant patients. A recent case report suggested that the administration of famotidine to a patient suffering from schizophrenia with peptic ulcer disease was associated with improvement in the deficit symptoms of schizophrenia. Famotidine is a potent highly selective H2 receptor antagonist which crosses the blood-brain barrier. Impressed by this finding, famotidine was prescribed to some of our treatment-resistant patients suffering from schizophrenia who demonstrated significant deficit symptoms of schizophrenia. The subjects were 12 (eight male, four female) treatment-resistant psychotic patients whose antipsychotic medications were augmented with famotidine in an open trial. They ranged in age from 21 to 48 years with a mean age of 32.75 years. Seven of the 12 subjects made significant improvement resulting in discharge from hospital. Paranoid disturbances as well as absence of comorbid substance use were predictors of good response to famotidine augmentation of the antipsychotic medications. The results implied that H2 receptor activity in the brain might play a role in the pathogenesis of deficit syndromes in schizophrenia. Further studies of this strategy are recommended, since it may open a window of understanding of the negative (deficit) syndrome and its treatment.

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  • Authors+Show Affiliations

    ,

    Department of Psychiatry, University of Western Ontario, London Psychiatric Hospital, Canada.

    , ,

    Source

    MeSH

    Adult
    Brain
    Famotidine
    Female
    Humans
    Male
    Middle Aged
    Psychiatric Status Rating Scales
    Schizophrenia
    Schizophrenic Psychology
    Severity of Illness Index
    Treatment Outcome

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    8204567

    Citation

    Oyewumi, L K., et al. "Famotidine as an Adjunct Treatment of Resistant Schizophrenia." Journal of Psychiatry & Neuroscience : JPN, vol. 19, no. 2, 1994, pp. 145-50.
    Oyewumi LK, Vollick D, Merskey H, et al. Famotidine as an adjunct treatment of resistant schizophrenia. J Psychiatry Neurosci. 1994;19(2):145-50.
    Oyewumi, L. K., Vollick, D., Merskey, H., & Plumb, C. (1994). Famotidine as an adjunct treatment of resistant schizophrenia. Journal of Psychiatry & Neuroscience : JPN, 19(2), pp. 145-50.
    Oyewumi LK, et al. Famotidine as an Adjunct Treatment of Resistant Schizophrenia. J Psychiatry Neurosci. 1994;19(2):145-50. PubMed PMID: 8204567.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Famotidine as an adjunct treatment of resistant schizophrenia. AU - Oyewumi,L K, AU - Vollick,D, AU - Merskey,H, AU - Plumb,C, PY - 1994/3/1/pubmed PY - 1994/3/1/medline PY - 1994/3/1/entrez SP - 145 EP - 50 JF - Journal of psychiatry & neuroscience : JPN JO - J Psychiatry Neurosci VL - 19 IS - 2 N2 - Some patients suffering from schizophrenia fail to respond to or tolerate adequate doses of available antipsychotic medications. Thus, innovative pharmacotherapeutic approaches, such as augmentation strategies, play an important role in the management of these treatment-resistant patients. A recent case report suggested that the administration of famotidine to a patient suffering from schizophrenia with peptic ulcer disease was associated with improvement in the deficit symptoms of schizophrenia. Famotidine is a potent highly selective H2 receptor antagonist which crosses the blood-brain barrier. Impressed by this finding, famotidine was prescribed to some of our treatment-resistant patients suffering from schizophrenia who demonstrated significant deficit symptoms of schizophrenia. The subjects were 12 (eight male, four female) treatment-resistant psychotic patients whose antipsychotic medications were augmented with famotidine in an open trial. They ranged in age from 21 to 48 years with a mean age of 32.75 years. Seven of the 12 subjects made significant improvement resulting in discharge from hospital. Paranoid disturbances as well as absence of comorbid substance use were predictors of good response to famotidine augmentation of the antipsychotic medications. The results implied that H2 receptor activity in the brain might play a role in the pathogenesis of deficit syndromes in schizophrenia. Further studies of this strategy are recommended, since it may open a window of understanding of the negative (deficit) syndrome and its treatment. SN - 1180-4882 UR - https://www.unboundmedicine.com/medline/citation/8204567/Famotidine_as_an_adjunct_treatment_of_resistant_schizophrenia_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/8204567/ DB - PRIME DP - Unbound Medicine ER -