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The failure of physiologic doses of reverse T3 to effect thyroid-pituitary function in man.
J Clin Endocrinol Metab. 1976 Aug; 43(2):478-81.JC

Abstract

Reverse T3 (3,3',5'-triiodothyronine, rT3), a major product of the peripheral monodeiodination of thyroxine (T4), was administered to normal male volunteers in doses sufficient to sustain an elevated serum rT3 concentration similar to that frequently observed in patients with nonthyroidal illness. No changes in basal serum T4, T3, TSH and prolactin concentrations, nor in the T3, TSH and prolactin responses to iv TRH were observed during rT3 administration. These findings suggest that physiologic increases in serum rT3 concentration probably do not inhibit T4 to T3 conversion or the anterior pituitary TSH and prolactin responses to thyrotropin-releasing hormone (TRH).

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

820712

Citation

Nicod, P, et al. "The Failure of Physiologic Doses of Reverse T3 to Effect Thyroid-pituitary Function in Man." The Journal of Clinical Endocrinology and Metabolism, vol. 43, no. 2, 1976, pp. 478-81.
Nicod P, Burger A, Strauch G, et al. The failure of physiologic doses of reverse T3 to effect thyroid-pituitary function in man. J Clin Endocrinol Metab. 1976;43(2):478-81.
Nicod, P., Burger, A., Strauch, G., Vagenakis, A. G., & Braverman, L. E. (1976). The failure of physiologic doses of reverse T3 to effect thyroid-pituitary function in man. The Journal of Clinical Endocrinology and Metabolism, 43(2), 478-81.
Nicod P, et al. The Failure of Physiologic Doses of Reverse T3 to Effect Thyroid-pituitary Function in Man. J Clin Endocrinol Metab. 1976;43(2):478-81. PubMed PMID: 820712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The failure of physiologic doses of reverse T3 to effect thyroid-pituitary function in man. AU - Nicod,P, AU - Burger,A, AU - Strauch,G, AU - Vagenakis,A G, AU - Braverman,L E, PY - 1976/8/1/pubmed PY - 1976/8/1/medline PY - 1976/8/1/entrez SP - 478 EP - 81 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 43 IS - 2 N2 - Reverse T3 (3,3',5'-triiodothyronine, rT3), a major product of the peripheral monodeiodination of thyroxine (T4), was administered to normal male volunteers in doses sufficient to sustain an elevated serum rT3 concentration similar to that frequently observed in patients with nonthyroidal illness. No changes in basal serum T4, T3, TSH and prolactin concentrations, nor in the T3, TSH and prolactin responses to iv TRH were observed during rT3 administration. These findings suggest that physiologic increases in serum rT3 concentration probably do not inhibit T4 to T3 conversion or the anterior pituitary TSH and prolactin responses to thyrotropin-releasing hormone (TRH). SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/820712/The_failure_of_physiologic_doses_of_reverse_T3_to_effect_thyroid_pituitary_function_in_man_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-43-2-478 DB - PRIME DP - Unbound Medicine ER -