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Some sensory neurons express neuropeptide Y receptors: potential paracrine inhibition of primary afferent nociceptors following peripheral nerve injury.
J Neurosci. 1994 Jun; 14(6):3958-68.JN

Abstract

Neuropeptide Y (NPY) has been suggested to exert antinociceptive actions by inhibiting the release of neurotransmitters from trigeminal and dorsal root ganglia (DRG) neurons, but the site of direct NPY action in vivo and the NPY receptor subtype mediating these effects are unknown. 125I-peptide YY (PYY) was used to localize and characterize NPY receptor binding sites in trigeminal ganglia, DRG, and spinal cord of the rat, rabbit, and monkey. In the rat, rabbit, and monkey, 5-20% of trigeminal ganglia and DRG neurons express NPY binding sites. Unilateral cuff-induced neuropathy or transection of the rat sciatic nerve did not significantly alter the density or number of DRG neurons expressing NPY receptors. A unimodal size distribution for L4 and L5 DRG neurons expressing NPY binding sites in the rat was determined, with a mean cross-sectional area of 947 microns 2. In the spinal cord the highest concentration of NPY receptors is found in laminae I, II, V, X, and Onuf's nucleus. Pharmacological experiments using selective Y1 and Y2 receptor antagonists suggest that Y2 is the prominent NPY receptor subtype expressed in trigeminal ganglia neurons, DRG neurons, and spinal cord. Previous studies have demonstrated that a population of large-diameter, presumably myelinated primary afferents express NPY after peripheral nerve injury. NPY released from these injured large-diameter DRG neurons may act in a paracrine fashion to block the transmission of nociceptive information from the small- and medium-diameter DRG neurons that constitutively express NPY receptors. NPY receptors are therefore uniquely positioned to inhibit primary afferent nociceptors directly, especially after peripheral nerve injury.

Authors+Show Affiliations

Molecular Neurobiology Laboratory, Veterans Administration Medical Center, Minneapolis, Minnesota 55417.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8207499

Citation

Mantyh, P W., et al. "Some Sensory Neurons Express Neuropeptide Y Receptors: Potential Paracrine Inhibition of Primary Afferent Nociceptors Following Peripheral Nerve Injury." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, vol. 14, no. 6, 1994, pp. 3958-68.
Mantyh PW, Allen CJ, Rogers S, et al. Some sensory neurons express neuropeptide Y receptors: potential paracrine inhibition of primary afferent nociceptors following peripheral nerve injury. J Neurosci. 1994;14(6):3958-68.
Mantyh, P. W., Allen, C. J., Rogers, S., DeMaster, E., Ghilardi, J. R., Mosconi, T., Kruger, L., Mannon, P. J., Taylor, I. L., & Vigna, S. R. (1994). Some sensory neurons express neuropeptide Y receptors: potential paracrine inhibition of primary afferent nociceptors following peripheral nerve injury. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 14(6), 3958-68.
Mantyh PW, et al. Some Sensory Neurons Express Neuropeptide Y Receptors: Potential Paracrine Inhibition of Primary Afferent Nociceptors Following Peripheral Nerve Injury. J Neurosci. 1994;14(6):3958-68. PubMed PMID: 8207499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Some sensory neurons express neuropeptide Y receptors: potential paracrine inhibition of primary afferent nociceptors following peripheral nerve injury. AU - Mantyh,P W, AU - Allen,C J, AU - Rogers,S, AU - DeMaster,E, AU - Ghilardi,J R, AU - Mosconi,T, AU - Kruger,L, AU - Mannon,P J, AU - Taylor,I L, AU - Vigna,S R, PY - 1994/6/1/pubmed PY - 1994/6/1/medline PY - 1994/6/1/entrez SP - 3958 EP - 68 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience JO - J. Neurosci. VL - 14 IS - 6 N2 - Neuropeptide Y (NPY) has been suggested to exert antinociceptive actions by inhibiting the release of neurotransmitters from trigeminal and dorsal root ganglia (DRG) neurons, but the site of direct NPY action in vivo and the NPY receptor subtype mediating these effects are unknown. 125I-peptide YY (PYY) was used to localize and characterize NPY receptor binding sites in trigeminal ganglia, DRG, and spinal cord of the rat, rabbit, and monkey. In the rat, rabbit, and monkey, 5-20% of trigeminal ganglia and DRG neurons express NPY binding sites. Unilateral cuff-induced neuropathy or transection of the rat sciatic nerve did not significantly alter the density or number of DRG neurons expressing NPY receptors. A unimodal size distribution for L4 and L5 DRG neurons expressing NPY binding sites in the rat was determined, with a mean cross-sectional area of 947 microns 2. In the spinal cord the highest concentration of NPY receptors is found in laminae I, II, V, X, and Onuf's nucleus. Pharmacological experiments using selective Y1 and Y2 receptor antagonists suggest that Y2 is the prominent NPY receptor subtype expressed in trigeminal ganglia neurons, DRG neurons, and spinal cord. Previous studies have demonstrated that a population of large-diameter, presumably myelinated primary afferents express NPY after peripheral nerve injury. NPY released from these injured large-diameter DRG neurons may act in a paracrine fashion to block the transmission of nociceptive information from the small- and medium-diameter DRG neurons that constitutively express NPY receptors. NPY receptors are therefore uniquely positioned to inhibit primary afferent nociceptors directly, especially after peripheral nerve injury. SN - 0270-6474 UR - https://www.unboundmedicine.com/medline/citation/8207499/Some_sensory_neurons_express_neuropeptide_Y_receptors:_potential_paracrine_inhibition_of_primary_afferent_nociceptors_following_peripheral_nerve_injury_ L2 - http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=8207499 DB - PRIME DP - Unbound Medicine ER -