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Evaluation of the rapid plasma reagin "teardrop" card test for screening of syphilis in field conditions.
Sex Transm Dis. 1993 Jul-Aug; 20(4):194-7.ST

Abstract

BACKGROUND AND OBJECTIVES

The availability of simple diagnostic methods may contribute to more efficient control of sexually transmitted diseases (STDs) in developing countries. For the detection of syphilis, a simple rapid plasma reagin (RPR) "teardrop" assay for finger-prick blood samples was developed in 1962. The reliability of this test is compared with RPR, Treponema pallidum hemagglutination assay (TPHA), and fluorescent treponemal antibody absorption (FTA-Abs) assays performed on venous blood samples.

GOAL OF THIS STUDY

To evaluate the potential usefulness of the finger-stick RPR teardrop assay for diagnosis of syphilis in settings with poor medical resources.

STUDY DESIGN

Pregnant women evaluated at two health centers in Pikine, Senegal were tested for STDs. The RPR teardrop assay was performed on plasma from blood samples obtained by finger prick, and standard RPR, TPHA, and FTA-Abs procedures were performed on serum obtained by vein puncture.

RESULTS

The sensitivity and specificity of the finger-prick RPR teardrop assay were 69.7% and 96.5%, respectively, and its reactivity was correlated with RPR serum antibody titer.

CONCLUSION

The finger-prick RPR teardrop assay is not a reliable alternative to the classic serum RPR test.

Authors+Show Affiliations

Department of Infection and Immunity, Institute of Tropical Medicine, Antwerp, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8211535

Citation

Van Dyck, E, et al. "Evaluation of the Rapid Plasma Reagin "teardrop" Card Test for Screening of Syphilis in Field Conditions." Sexually Transmitted Diseases, vol. 20, no. 4, 1993, pp. 194-7.
Van Dyck E, Van de Velden L, Ndoye I, et al. Evaluation of the rapid plasma reagin "teardrop" card test for screening of syphilis in field conditions. Sex Transm Dis. 1993;20(4):194-7.
Van Dyck, E., Van de Velden, L., Ndoye, I., Piot, P., & Meheus, A. (1993). Evaluation of the rapid plasma reagin "teardrop" card test for screening of syphilis in field conditions. Sexually Transmitted Diseases, 20(4), 194-7.
Van Dyck E, et al. Evaluation of the Rapid Plasma Reagin "teardrop" Card Test for Screening of Syphilis in Field Conditions. Sex Transm Dis. 1993 Jul-Aug;20(4):194-7. PubMed PMID: 8211535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the rapid plasma reagin "teardrop" card test for screening of syphilis in field conditions. AU - Van Dyck,E, AU - Van de Velden,L, AU - Ndoye,I, AU - Piot,P, AU - Meheus,A, PY - 1993/7/1/pubmed PY - 1993/7/1/medline PY - 1993/7/1/entrez KW - Africa KW - Africa South Of The Sahara KW - Comparative Studies KW - Demographic Factors KW - Developing Countries KW - Error Sources KW - Examinations And Diagnoses KW - False Negative Reactions KW - False Positive Reactions KW - French Speaking Africa KW - Hematologic Tests KW - Laboratory Examinations And Diagnoses KW - Laboratory Procedures KW - Measurement KW - Population KW - Population Characteristics KW - Pregnant Women KW - Reliability KW - Research Methodology KW - Research Report KW - Screening KW - Senegal KW - Studies KW - Western Africa SP - 194 EP - 7 JF - Sexually transmitted diseases JO - Sex Transm Dis VL - 20 IS - 4 N2 - BACKGROUND AND OBJECTIVES: The availability of simple diagnostic methods may contribute to more efficient control of sexually transmitted diseases (STDs) in developing countries. For the detection of syphilis, a simple rapid plasma reagin (RPR) "teardrop" assay for finger-prick blood samples was developed in 1962. The reliability of this test is compared with RPR, Treponema pallidum hemagglutination assay (TPHA), and fluorescent treponemal antibody absorption (FTA-Abs) assays performed on venous blood samples. GOAL OF THIS STUDY: To evaluate the potential usefulness of the finger-stick RPR teardrop assay for diagnosis of syphilis in settings with poor medical resources. STUDY DESIGN: Pregnant women evaluated at two health centers in Pikine, Senegal were tested for STDs. The RPR teardrop assay was performed on plasma from blood samples obtained by finger prick, and standard RPR, TPHA, and FTA-Abs procedures were performed on serum obtained by vein puncture. RESULTS: The sensitivity and specificity of the finger-prick RPR teardrop assay were 69.7% and 96.5%, respectively, and its reactivity was correlated with RPR serum antibody titer. CONCLUSION: The finger-prick RPR teardrop assay is not a reliable alternative to the classic serum RPR test. SN - 0148-5717 UR - https://www.unboundmedicine.com/medline/citation/8211535/Evaluation_of_the_rapid_plasma_reagin_"teardrop"_card_test_for_screening_of_syphilis_in_field_conditions_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8211535.ui DB - PRIME DP - Unbound Medicine ER -