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Pathological markers associated with normal aging and dementia in the elderly.
Ann Neurol. 1993 Oct; 34(4):566-73.AN

Abstract

We investigated the associations of pathological markers of Alzheimer's disease (AD) and diffuse Lewy body disease as well as possible markers of vascular dementia with cognitive function in a sample of 20 nondemented and 35 demented subjects (median age of both groups, 88 years) who had been studied prospectively for 4.0 +/- 2.1 years. Very old demented subjects almost always had nonneuritic senile plaques, but over half had no neuritic senile plaques and little other AD pathology. Five subjects had cortical Lewy bodies; all were demented. We propose that hippocampal sclerosis, leukoencephalopathy, and multiple lacunae are possible markers of vascular dementia. When grouped together, these markers were significantly associated with dementia and occurred in 40% of demented subjects. As the relative frequency of neuritic markers of AD (and possibly AD itself) declines in the tenth decade, vascular dementia may become an increasingly important type of dementia.

Authors+Show Affiliations

Department of Neurology, Albert Einstein College of Medicine, Bronx, NY.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8215244

Citation

Crystal, H A., et al. "Pathological Markers Associated With Normal Aging and Dementia in the Elderly." Annals of Neurology, vol. 34, no. 4, 1993, pp. 566-73.
Crystal HA, Dickson DW, Sliwinski MJ, et al. Pathological markers associated with normal aging and dementia in the elderly. Ann Neurol. 1993;34(4):566-73.
Crystal, H. A., Dickson, D. W., Sliwinski, M. J., Lipton, R. B., Grober, E., Marks-Nelson, H., & Antis, P. (1993). Pathological markers associated with normal aging and dementia in the elderly. Annals of Neurology, 34(4), 566-73.
Crystal HA, et al. Pathological Markers Associated With Normal Aging and Dementia in the Elderly. Ann Neurol. 1993;34(4):566-73. PubMed PMID: 8215244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathological markers associated with normal aging and dementia in the elderly. AU - Crystal,H A, AU - Dickson,D W, AU - Sliwinski,M J, AU - Lipton,R B, AU - Grober,E, AU - Marks-Nelson,H, AU - Antis,P, PY - 1993/10/1/pubmed PY - 1993/10/1/medline PY - 1993/10/1/entrez SP - 566 EP - 73 JF - Annals of neurology JO - Ann Neurol VL - 34 IS - 4 N2 - We investigated the associations of pathological markers of Alzheimer's disease (AD) and diffuse Lewy body disease as well as possible markers of vascular dementia with cognitive function in a sample of 20 nondemented and 35 demented subjects (median age of both groups, 88 years) who had been studied prospectively for 4.0 +/- 2.1 years. Very old demented subjects almost always had nonneuritic senile plaques, but over half had no neuritic senile plaques and little other AD pathology. Five subjects had cortical Lewy bodies; all were demented. We propose that hippocampal sclerosis, leukoencephalopathy, and multiple lacunae are possible markers of vascular dementia. When grouped together, these markers were significantly associated with dementia and occurred in 40% of demented subjects. As the relative frequency of neuritic markers of AD (and possibly AD itself) declines in the tenth decade, vascular dementia may become an increasingly important type of dementia. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/8215244/Pathological_markers_associated_with_normal_aging_and_dementia_in_the_elderly_ DB - PRIME DP - Unbound Medicine ER -