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Vasodilator effect of adrenomedullin and calcitonin gene-related peptide receptors in rat mesenteric vascular beds.
Biochem Biophys Res Commun. 1993 Oct 15; 196(1):245-51.BB

Abstract

The effect of adrenomedullin, a novel peptide of 52 amino acids, on vascular tone was investigated in the perfused rat mesenteric vascular bed. In the vasculature contracted with methoxamine, perfusion of adrenomedullin (10(-11)-10(-7) M) caused a concentration-dependent decrease in perfusion pressure due to vasodilation. Additionally, a bolus infusion of adrenomedullin (300 and 500 pmol) produced a long-lasting vasodilator response, which was not affected in the presence of atropine (10(-7) M) and propranolol (10(-7) M). However, this response was inhibited in the presence of CGRP [8-37] (10(-6) M), an antagonist for CGRP receptor. These results suggest that adrenomedullin induces nonadrenergic and noncholinergic vasodilation in which CGRP receptors may be involved.

Authors+Show Affiliations

Department of Pharmacology, Miyazaki Medical College, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8216298

Citation

Nuki, C, et al. "Vasodilator Effect of Adrenomedullin and Calcitonin Gene-related Peptide Receptors in Rat Mesenteric Vascular Beds." Biochemical and Biophysical Research Communications, vol. 196, no. 1, 1993, pp. 245-51.
Nuki C, Kawasaki H, Kitamura K, et al. Vasodilator effect of adrenomedullin and calcitonin gene-related peptide receptors in rat mesenteric vascular beds. Biochem Biophys Res Commun. 1993;196(1):245-51.
Nuki, C., Kawasaki, H., Kitamura, K., Takenaga, M., Kangawa, K., Eto, T., & Wada, A. (1993). Vasodilator effect of adrenomedullin and calcitonin gene-related peptide receptors in rat mesenteric vascular beds. Biochemical and Biophysical Research Communications, 196(1), 245-51.
Nuki C, et al. Vasodilator Effect of Adrenomedullin and Calcitonin Gene-related Peptide Receptors in Rat Mesenteric Vascular Beds. Biochem Biophys Res Commun. 1993 Oct 15;196(1):245-51. PubMed PMID: 8216298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vasodilator effect of adrenomedullin and calcitonin gene-related peptide receptors in rat mesenteric vascular beds. AU - Nuki,C, AU - Kawasaki,H, AU - Kitamura,K, AU - Takenaga,M, AU - Kangawa,K, AU - Eto,T, AU - Wada,A, PY - 1993/10/15/pubmed PY - 1993/10/15/medline PY - 1993/10/15/entrez SP - 245 EP - 51 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 196 IS - 1 N2 - The effect of adrenomedullin, a novel peptide of 52 amino acids, on vascular tone was investigated in the perfused rat mesenteric vascular bed. In the vasculature contracted with methoxamine, perfusion of adrenomedullin (10(-11)-10(-7) M) caused a concentration-dependent decrease in perfusion pressure due to vasodilation. Additionally, a bolus infusion of adrenomedullin (300 and 500 pmol) produced a long-lasting vasodilator response, which was not affected in the presence of atropine (10(-7) M) and propranolol (10(-7) M). However, this response was inhibited in the presence of CGRP [8-37] (10(-6) M), an antagonist for CGRP receptor. These results suggest that adrenomedullin induces nonadrenergic and noncholinergic vasodilation in which CGRP receptors may be involved. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/8216298/Vasodilator_effect_of_adrenomedullin_and_calcitonin_gene_related_peptide_receptors_in_rat_mesenteric_vascular_beds_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(83)72241-2 DB - PRIME DP - Unbound Medicine ER -