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The diagnosis and treatment of gastro-oesophageal reflux disease in infants and children.
Ann Med 1993; 25(4):323-8AM

Abstract

Gastro-oesophageal reflux is a common phenomenon in infants, and is an aspecific complaint. The balance between negligence and overconcern is therefore very difficult to make, and requires experienced physicians. The approach in infants with uncomplicated reflux consists of non-drug treatment and reassurance of the parents about the almost physiological nature of the regurgitations of the baby. If the parents persist in their complaints, the administration of prokinetics such as cisapride can be considered before performing investigations (oesophageal pH monitoring). The efficacy and the lack of side-effects of cisapride makes this the drug of choice. The frequency of side-effects of other drugs necessitates the diagnosis of reflux disease before their administration. Upper gastrointestinal tract endoscopy is the investigation of choice in children suspected of reflux oesophagitis. In the majority of cases, the efficacy of cisapride, H2-blockers and Na-K-ATP-ase-blockers should be given a chance. Unusual presentations, such as chronic respiratory disease, as a manifestation of reflux disease should be confirmed with oesophageal pH monitoring.

Authors+Show Affiliations

Academisch Ziekenhuis Kinderen, Vrije Universiteit Brussel, Belgium.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8217096

Citation

Vandenplas, Y. "The Diagnosis and Treatment of Gastro-oesophageal Reflux Disease in Infants and Children." Annals of Medicine, vol. 25, no. 4, 1993, pp. 323-8.
Vandenplas Y. The diagnosis and treatment of gastro-oesophageal reflux disease in infants and children. Ann Med. 1993;25(4):323-8.
Vandenplas, Y. (1993). The diagnosis and treatment of gastro-oesophageal reflux disease in infants and children. Annals of Medicine, 25(4), pp. 323-8.
Vandenplas Y. The Diagnosis and Treatment of Gastro-oesophageal Reflux Disease in Infants and Children. Ann Med. 1993;25(4):323-8. PubMed PMID: 8217096.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The diagnosis and treatment of gastro-oesophageal reflux disease in infants and children. A1 - Vandenplas,Y, PY - 1993/8/1/pubmed PY - 1993/8/1/medline PY - 1993/8/1/entrez SP - 323 EP - 8 JF - Annals of medicine JO - Ann. Med. VL - 25 IS - 4 N2 - Gastro-oesophageal reflux is a common phenomenon in infants, and is an aspecific complaint. The balance between negligence and overconcern is therefore very difficult to make, and requires experienced physicians. The approach in infants with uncomplicated reflux consists of non-drug treatment and reassurance of the parents about the almost physiological nature of the regurgitations of the baby. If the parents persist in their complaints, the administration of prokinetics such as cisapride can be considered before performing investigations (oesophageal pH monitoring). The efficacy and the lack of side-effects of cisapride makes this the drug of choice. The frequency of side-effects of other drugs necessitates the diagnosis of reflux disease before their administration. Upper gastrointestinal tract endoscopy is the investigation of choice in children suspected of reflux oesophagitis. In the majority of cases, the efficacy of cisapride, H2-blockers and Na-K-ATP-ase-blockers should be given a chance. Unusual presentations, such as chronic respiratory disease, as a manifestation of reflux disease should be confirmed with oesophageal pH monitoring. SN - 0785-3890 UR - https://www.unboundmedicine.com/medline/citation/8217096/The_diagnosis_and_treatment_of_gastro_oesophageal_reflux_disease_in_infants_and_children_ L2 - http://www.tandfonline.com/doi/full/10.3109/07853899309147292 DB - PRIME DP - Unbound Medicine ER -