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Suppression of prolactin secretion by L-dopa in the stalk-sectioned rhesus monkey.
J Clin Endocrinol Metab 1976; 43(3):638-42JC

Abstract

The effects of iv administration of L-dopa on serum prolactin were studied in both normal female rhesus monkeys and in monkeys in which the pituitary stalk had been previously sectioned. Revascularization of the pituitary gland was prevented by the insertion of a silastic barrier over the diaphragma sellae. Prolactin secretion was increased in all stalk-sectioned monkeys and, in contrast to intact animals, chlorpromazine administration was ineffective in further releasing prolactin. In both normal and stalk-sectioned monkeys, iv administration of L-dopa (3-120 mg) significantly inhibited prolactin release from the pituitary (P less than .005 normal; P less than .001 stalk section). L-dopa also suppressed the TRH-induced release of prolactin in both groups. These results indicate that L-dopa or dopamine may act directly on the anterior pituitary to inhibit prolactin secretion.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

821963

Citation

Diefenbach, W P., et al. "Suppression of Prolactin Secretion By L-dopa in the Stalk-sectioned Rhesus Monkey." The Journal of Clinical Endocrinology and Metabolism, vol. 43, no. 3, 1976, pp. 638-42.
Diefenbach WP, Carmel PW, Frantz AG, et al. Suppression of prolactin secretion by L-dopa in the stalk-sectioned rhesus monkey. J Clin Endocrinol Metab. 1976;43(3):638-42.
Diefenbach, W. P., Carmel, P. W., Frantz, A. G., & Ferin, M. (1976). Suppression of prolactin secretion by L-dopa in the stalk-sectioned rhesus monkey. The Journal of Clinical Endocrinology and Metabolism, 43(3), pp. 638-42.
Diefenbach WP, et al. Suppression of Prolactin Secretion By L-dopa in the Stalk-sectioned Rhesus Monkey. J Clin Endocrinol Metab. 1976;43(3):638-42. PubMed PMID: 821963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Suppression of prolactin secretion by L-dopa in the stalk-sectioned rhesus monkey. AU - Diefenbach,W P, AU - Carmel,P W, AU - Frantz,A G, AU - Ferin,M, PY - 1976/9/1/pubmed PY - 1976/9/1/medline PY - 1976/9/1/entrez SP - 638 EP - 42 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 43 IS - 3 N2 - The effects of iv administration of L-dopa on serum prolactin were studied in both normal female rhesus monkeys and in monkeys in which the pituitary stalk had been previously sectioned. Revascularization of the pituitary gland was prevented by the insertion of a silastic barrier over the diaphragma sellae. Prolactin secretion was increased in all stalk-sectioned monkeys and, in contrast to intact animals, chlorpromazine administration was ineffective in further releasing prolactin. In both normal and stalk-sectioned monkeys, iv administration of L-dopa (3-120 mg) significantly inhibited prolactin release from the pituitary (P less than .005 normal; P less than .001 stalk section). L-dopa also suppressed the TRH-induced release of prolactin in both groups. These results indicate that L-dopa or dopamine may act directly on the anterior pituitary to inhibit prolactin secretion. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/821963/Suppression_of_prolactin_secretion_by_L_dopa_in_the_stalk_sectioned_rhesus_monkey_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-43-3-638 DB - PRIME DP - Unbound Medicine ER -