Tags

Type your tag names separated by a space and hit enter

Cigarette smoking and alcohol consumption by parents of children with acute myeloid leukemia: an analysis within morphological subgroups--a report from the Childrens Cancer Group.
Cancer Epidemiol Biomarkers Prev. 1993 Sep-Oct; 2(5):433-9.CE

Abstract

Data from a case-control study of childhood acute myeloid leukemia (AML) including 187 matched case-control pairs were examined for evidence of associations between parental cigarette smoking and alcohol consumption and the subsequent development of childhood AML. The cases were stratified by French-American-British morphology in order to evaluate potential differences in risk based on this classification system. There was little evidence of any association between cigarette smoking by parents during the index pregnancy and childhood AML. There was some evidence of an increased risk of AML among children who were diagnosed at or before 2 years of age and whose mothers reported consuming alcohol during their pregnancies (odds ratio, 3.00; 95% confidence interval, 1.23 to 8.35). This finding appeared to be especially pronounced for AML with a monocytic component (M4/M5) (odds ratio, 9.00; 95% confidence interval, 1.25 to 394.5), but a cautious interpretation of these data are advised because of the small number of subjects included in this subgroup analysis. Since this is one of the first case-control studies to evaluate specific French-American-British subtypes of AML, these results may be viewed as generating hypotheses. It is suggested that future studies of childhood AML include: (a) a sufficient number of cases to permit an evaluation of the morphological classification of the cases; and (b) additional questions on the alcohol consumption of the mother during the time of her pregnancy with the index child.

Authors+Show Affiliations

Division of Epidemiology, University of Minnesota, Minneapolis 55454.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8220087

Citation

Severson, R K., et al. "Cigarette Smoking and Alcohol Consumption By Parents of Children With Acute Myeloid Leukemia: an Analysis Within Morphological Subgroups--a Report From the Childrens Cancer Group." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 2, no. 5, 1993, pp. 433-9.
Severson RK, Buckley JD, Woods WG, et al. Cigarette smoking and alcohol consumption by parents of children with acute myeloid leukemia: an analysis within morphological subgroups--a report from the Childrens Cancer Group. Cancer Epidemiol Biomarkers Prev. 1993;2(5):433-9.
Severson, R. K., Buckley, J. D., Woods, W. G., Benjamin, D., & Robison, L. L. (1993). Cigarette smoking and alcohol consumption by parents of children with acute myeloid leukemia: an analysis within morphological subgroups--a report from the Childrens Cancer Group. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 2(5), 433-9.
Severson RK, et al. Cigarette Smoking and Alcohol Consumption By Parents of Children With Acute Myeloid Leukemia: an Analysis Within Morphological Subgroups--a Report From the Childrens Cancer Group. Cancer Epidemiol Biomarkers Prev. 1993 Sep-Oct;2(5):433-9. PubMed PMID: 8220087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cigarette smoking and alcohol consumption by parents of children with acute myeloid leukemia: an analysis within morphological subgroups--a report from the Childrens Cancer Group. AU - Severson,R K, AU - Buckley,J D, AU - Woods,W G, AU - Benjamin,D, AU - Robison,L L, PY - 1993/9/1/pubmed PY - 1993/9/1/medline PY - 1993/9/1/entrez SP - 433 EP - 9 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 2 IS - 5 N2 - Data from a case-control study of childhood acute myeloid leukemia (AML) including 187 matched case-control pairs were examined for evidence of associations between parental cigarette smoking and alcohol consumption and the subsequent development of childhood AML. The cases were stratified by French-American-British morphology in order to evaluate potential differences in risk based on this classification system. There was little evidence of any association between cigarette smoking by parents during the index pregnancy and childhood AML. There was some evidence of an increased risk of AML among children who were diagnosed at or before 2 years of age and whose mothers reported consuming alcohol during their pregnancies (odds ratio, 3.00; 95% confidence interval, 1.23 to 8.35). This finding appeared to be especially pronounced for AML with a monocytic component (M4/M5) (odds ratio, 9.00; 95% confidence interval, 1.25 to 394.5), but a cautious interpretation of these data are advised because of the small number of subjects included in this subgroup analysis. Since this is one of the first case-control studies to evaluate specific French-American-British subtypes of AML, these results may be viewed as generating hypotheses. It is suggested that future studies of childhood AML include: (a) a sufficient number of cases to permit an evaluation of the morphological classification of the cases; and (b) additional questions on the alcohol consumption of the mother during the time of her pregnancy with the index child. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/8220087/Cigarette_smoking_and_alcohol_consumption_by_parents_of_children_with_acute_myeloid_leukemia:_an_analysis_within_morphological_subgroups__a_report_from_the_Childrens_Cancer_Group_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=8220087 DB - PRIME DP - Unbound Medicine ER -