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A case of sellar chordoma mimicking a non-functioning pituitary adenoma with survival of more than 10 years.
Noshuyo Byori. 1993; 10(2):103-6.NB

Abstract

A rare case of sellar chordoma occurring in a 67-year-old woman who survived for more than 10 years is presented. Clinical signs and symptoms masqueraded as a non-functioning pituitary adenoma with visual disturbance and hypopituitarism. Initial computed tomography (CT) showed an intrasellar mixed dense mass with suprasellar extension, accompanied by non-homogeneous contrast enhancement. Partial removal of the mass was accomplished via right fronto-temporal craniotomy. Histological examination revealed a typical chordoma with no malignancy. After postoperative irradiation, the patient was discharged with clinical improvement. Serial CT and magnetic resonance imaging 8 years after treatment disclosed a regrowth of the intrasellar lesion, which extended to the sphenoid sinus and clivus, accompanied by non-homogeneous contrast enhancement. The patient underwent subtotal removal of the recurrent tumor through a sublabial transsphenoidal approach. Histological examination confirmed the previous diagnosis. Immunohistochemical study demonstrated positive cytoplasmic expression of vimentin, epithelial membrane antigen, keratin and S-100 protein, in contrast with a lack of appearance of carcinoembryonic antigen. After reoperation, she completely recovered and has survived for more than 10 years with good quality of life.

Authors+Show Affiliations

Department of Neurosurgery, Shimane Medical University.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

8220788

Citation

Kagawa, T, et al. "A Case of Sellar Chordoma Mimicking a Non-functioning Pituitary Adenoma With Survival of More Than 10 Years." Noshuyo Byori = Brain Tumor Pathology, vol. 10, no. 2, 1993, pp. 103-6.
Kagawa T, Takamura M, Moritake K, et al. A case of sellar chordoma mimicking a non-functioning pituitary adenoma with survival of more than 10 years. Noshuyo Byori. 1993;10(2):103-6.
Kagawa, T., Takamura, M., Moritake, K., Tsutsumi, A., & Yamasaki, T. (1993). A case of sellar chordoma mimicking a non-functioning pituitary adenoma with survival of more than 10 years. Noshuyo Byori = Brain Tumor Pathology, 10(2), 103-6.
Kagawa T, et al. A Case of Sellar Chordoma Mimicking a Non-functioning Pituitary Adenoma With Survival of More Than 10 Years. Noshuyo Byori. 1993;10(2):103-6. PubMed PMID: 8220788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case of sellar chordoma mimicking a non-functioning pituitary adenoma with survival of more than 10 years. AU - Kagawa,T, AU - Takamura,M, AU - Moritake,K, AU - Tsutsumi,A, AU - Yamasaki,T, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 103 EP - 6 JF - Noshuyo byori = Brain tumor pathology JO - Noshuyo Byori VL - 10 IS - 2 N2 - A rare case of sellar chordoma occurring in a 67-year-old woman who survived for more than 10 years is presented. Clinical signs and symptoms masqueraded as a non-functioning pituitary adenoma with visual disturbance and hypopituitarism. Initial computed tomography (CT) showed an intrasellar mixed dense mass with suprasellar extension, accompanied by non-homogeneous contrast enhancement. Partial removal of the mass was accomplished via right fronto-temporal craniotomy. Histological examination revealed a typical chordoma with no malignancy. After postoperative irradiation, the patient was discharged with clinical improvement. Serial CT and magnetic resonance imaging 8 years after treatment disclosed a regrowth of the intrasellar lesion, which extended to the sphenoid sinus and clivus, accompanied by non-homogeneous contrast enhancement. The patient underwent subtotal removal of the recurrent tumor through a sublabial transsphenoidal approach. Histological examination confirmed the previous diagnosis. Immunohistochemical study demonstrated positive cytoplasmic expression of vimentin, epithelial membrane antigen, keratin and S-100 protein, in contrast with a lack of appearance of carcinoembryonic antigen. After reoperation, she completely recovered and has survived for more than 10 years with good quality of life. SN - 0914-8108 UR - https://www.unboundmedicine.com/medline/citation/8220788/A_case_of_sellar_chordoma_mimicking_a_non_functioning_pituitary_adenoma_with_survival_of_more_than_10_years_ L2 - http://www.diseaseinfosearch.org/result/1380 DB - PRIME DP - Unbound Medicine ER -