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A case of sellar chordoma mimicking a non-functioning pituitary adenoma with survival of more than 10 years.
Noshuyo Byori. 1993; 10(2):103-6.NB

Abstract

A rare case of sellar chordoma occurring in a 67-year-old woman who survived for more than 10 years is presented. Clinical signs and symptoms masqueraded as a non-functioning pituitary adenoma with visual disturbance and hypopituitarism. Initial computed tomography (CT) showed an intrasellar mixed dense mass with suprasellar extension, accompanied by non-homogeneous contrast enhancement. Partial removal of the mass was accomplished via right fronto-temporal craniotomy. Histological examination revealed a typical chordoma with no malignancy. After postoperative irradiation, the patient was discharged with clinical improvement. Serial CT and magnetic resonance imaging 8 years after treatment disclosed a regrowth of the intrasellar lesion, which extended to the sphenoid sinus and clivus, accompanied by non-homogeneous contrast enhancement. The patient underwent subtotal removal of the recurrent tumor through a sublabial transsphenoidal approach. Histological examination confirmed the previous diagnosis. Immunohistochemical study demonstrated positive cytoplasmic expression of vimentin, epithelial membrane antigen, keratin and S-100 protein, in contrast with a lack of appearance of carcinoembryonic antigen. After reoperation, she completely recovered and has survived for more than 10 years with good quality of life.

Authors+Show Affiliations

Kagawa T
Department of Neurosurgery, Shimane Medical University.
Takamura M
No affiliation info available
Moritake K
No affiliation info available
Tsutsumi A
No affiliation info available
Yamasaki T
No affiliation info available

MeSH

AdenomaAgedChordomaDiagnosis, DifferentialFemaleHumansImmunohistochemistryMagnetic Resonance ImagingMortalityNeoplasm Recurrence, LocalPituitary NeoplasmsSkull NeoplasmsTime FactorsTomography, X-Ray Computed

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

8220788

Citation

Kagawa, T, et al. "A Case of Sellar Chordoma Mimicking a Non-functioning Pituitary Adenoma With Survival of More Than 10 Years." Noshuyo Byori = Brain Tumor Pathology, vol. 10, no. 2, 1993, pp. 103-6.
Kagawa T, Takamura M, Moritake K, et al. A case of sellar chordoma mimicking a non-functioning pituitary adenoma with survival of more than 10 years. Noshuyo Byori. 1993;10(2):103-6.
Kagawa, T., Takamura, M., Moritake, K., Tsutsumi, A., & Yamasaki, T. (1993). A case of sellar chordoma mimicking a non-functioning pituitary adenoma with survival of more than 10 years. Noshuyo Byori = Brain Tumor Pathology, 10(2), 103-6.
Kagawa T, et al. A Case of Sellar Chordoma Mimicking a Non-functioning Pituitary Adenoma With Survival of More Than 10 Years. Noshuyo Byori. 1993;10(2):103-6. PubMed PMID: 8220788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case of sellar chordoma mimicking a non-functioning pituitary adenoma with survival of more than 10 years. AU - Kagawa,T, AU - Takamura,M, AU - Moritake,K, AU - Tsutsumi,A, AU - Yamasaki,T, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 103 EP - 6 JF - Noshuyo byori = Brain tumor pathology JO - Noshuyo Byori VL - 10 IS - 2 N2 - A rare case of sellar chordoma occurring in a 67-year-old woman who survived for more than 10 years is presented. Clinical signs and symptoms masqueraded as a non-functioning pituitary adenoma with visual disturbance and hypopituitarism. Initial computed tomography (CT) showed an intrasellar mixed dense mass with suprasellar extension, accompanied by non-homogeneous contrast enhancement. Partial removal of the mass was accomplished via right fronto-temporal craniotomy. Histological examination revealed a typical chordoma with no malignancy. After postoperative irradiation, the patient was discharged with clinical improvement. Serial CT and magnetic resonance imaging 8 years after treatment disclosed a regrowth of the intrasellar lesion, which extended to the sphenoid sinus and clivus, accompanied by non-homogeneous contrast enhancement. The patient underwent subtotal removal of the recurrent tumor through a sublabial transsphenoidal approach. Histological examination confirmed the previous diagnosis. Immunohistochemical study demonstrated positive cytoplasmic expression of vimentin, epithelial membrane antigen, keratin and S-100 protein, in contrast with a lack of appearance of carcinoembryonic antigen. After reoperation, she completely recovered and has survived for more than 10 years with good quality of life. SN - 0914-8108 UR - https://www.unboundmedicine.com/medline/citation/8220788/A_case_of_sellar_chordoma_mimicking_a_non_functioning_pituitary_adenoma_with_survival_of_more_than_10_years_ L2 - http://www.diseaseinfosearch.org/result/1380 DB - PRIME DP - Unbound Medicine ER -