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Prevalence of intolerance to food additives among Danish school children.
Pediatr Allergy Immunol. 1993 Aug; 4(3):123-9.PA

Abstract

The prevalence of intolerance to food additives was assessed in a group of unselected school children aged 5-16 years. A study group of 271 children was selected on the basis of the results of a questionnaire on atopic disease answered by 4,274 (86%) school children in the municipality of Viborg, Denmark. The children in the study group followed an elimination diet for two weeks before they were challenged with a mixture of food preservatives, colourings and flavours. The challenge was open and the additives were prepared as a fizzy lemonade. If the open challenge was positive, a double-blind placebo controlled challenge with gelatine capsules was performed. The study included 281 children, 10 were excluded, and the remaining 271 children were given the open challenge (98 healthy controls and 173 with atopic symptoms). The open challenge was negative in all 98 healthy control children who had not reported any atopic symptoms. Of the 173 children reporting present or previous atopic disease 17 had a positive open challenge. Of these 17 children 1 experienced gastrointestinal symptoms, 13 reacted with aggravation of atopic eczema, and 3 with urticaria. Twelve of these 17 children went through the double-blind challenge which was positive in 6 cases. Five of these 6 children had positive reactions to synthetic colourings and 1 to citric acid. No serious reactions were seen. Based upon calculations of the results from this study and an earlier multi-center study in children referred to hospital clinics, the prevalence of intolerance to food additives in school children is estimated to be 1-2%.

Authors+Show Affiliations

Department of Pediatrics, Viborg Hospital, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8220800

Citation

Fuglsang, G, et al. "Prevalence of Intolerance to Food Additives Among Danish School Children." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 4, no. 3, 1993, pp. 123-9.
Fuglsang G, Madsen C, Saval P, et al. Prevalence of intolerance to food additives among Danish school children. Pediatr Allergy Immunol. 1993;4(3):123-9.
Fuglsang, G., Madsen, C., Saval, P., & Osterballe, O. (1993). Prevalence of intolerance to food additives among Danish school children. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 4(3), 123-9.
Fuglsang G, et al. Prevalence of Intolerance to Food Additives Among Danish School Children. Pediatr Allergy Immunol. 1993;4(3):123-9. PubMed PMID: 8220800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of intolerance to food additives among Danish school children. AU - Fuglsang,G, AU - Madsen,C, AU - Saval,P, AU - Osterballe,O, PY - 1993/8/1/pubmed PY - 1993/8/1/medline PY - 1993/8/1/entrez SP - 123 EP - 9 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 4 IS - 3 N2 - The prevalence of intolerance to food additives was assessed in a group of unselected school children aged 5-16 years. A study group of 271 children was selected on the basis of the results of a questionnaire on atopic disease answered by 4,274 (86%) school children in the municipality of Viborg, Denmark. The children in the study group followed an elimination diet for two weeks before they were challenged with a mixture of food preservatives, colourings and flavours. The challenge was open and the additives were prepared as a fizzy lemonade. If the open challenge was positive, a double-blind placebo controlled challenge with gelatine capsules was performed. The study included 281 children, 10 were excluded, and the remaining 271 children were given the open challenge (98 healthy controls and 173 with atopic symptoms). The open challenge was negative in all 98 healthy control children who had not reported any atopic symptoms. Of the 173 children reporting present or previous atopic disease 17 had a positive open challenge. Of these 17 children 1 experienced gastrointestinal symptoms, 13 reacted with aggravation of atopic eczema, and 3 with urticaria. Twelve of these 17 children went through the double-blind challenge which was positive in 6 cases. Five of these 6 children had positive reactions to synthetic colourings and 1 to citric acid. No serious reactions were seen. Based upon calculations of the results from this study and an earlier multi-center study in children referred to hospital clinics, the prevalence of intolerance to food additives in school children is estimated to be 1-2%. SN - 0905-6157 UR - https://www.unboundmedicine.com/medline/citation/8220800/Prevalence_of_intolerance_to_food_additives_among_Danish_school_children_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0905-6157&date=1993&volume=4&issue=3&spage=123 DB - PRIME DP - Unbound Medicine ER -