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Oxidative mechanisms in carcinogenesis.
Br Med Bull 1993; 49(3):523-44BM

Abstract

Cancer in humans and animals is a multistep disease process. In this process, a single cell can develop from an otherwise normal tissue into a malignancy that can eventually destroy the organism. The complex series of cellular and molecular changes that occur through the development of cancers can be mediated by a diversity of endogenous and environmental stimuli. Active oxygen species and other free radicals have long been known to be mutagenic; further, these agents have more recently emerged as mediators of the other phenotypic and genotypic changes that lead from mutation to neoplasia. Free radical production is ubiquitous in all respiring organisms, and is enhanced in many disease states, by carcinogen exposure, and under conditions of stress. Free radicals may therefore contribute widely to cancer development in humans. This review explores the molecular mechanisms through which free radicals can participate in the carcinogenic process.

Authors+Show Affiliations

Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

8221020

Citation

Guyton, K Z., and T W. Kensler. "Oxidative Mechanisms in Carcinogenesis." British Medical Bulletin, vol. 49, no. 3, 1993, pp. 523-44.
Guyton KZ, Kensler TW. Oxidative mechanisms in carcinogenesis. Br Med Bull. 1993;49(3):523-44.
Guyton, K. Z., & Kensler, T. W. (1993). Oxidative mechanisms in carcinogenesis. British Medical Bulletin, 49(3), pp. 523-44.
Guyton KZ, Kensler TW. Oxidative Mechanisms in Carcinogenesis. Br Med Bull. 1993;49(3):523-44. PubMed PMID: 8221020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative mechanisms in carcinogenesis. AU - Guyton,K Z, AU - Kensler,T W, PY - 1993/7/1/pubmed PY - 1993/7/1/medline PY - 1993/7/1/entrez SP - 523 EP - 44 JF - British medical bulletin JO - Br. Med. Bull. VL - 49 IS - 3 N2 - Cancer in humans and animals is a multistep disease process. In this process, a single cell can develop from an otherwise normal tissue into a malignancy that can eventually destroy the organism. The complex series of cellular and molecular changes that occur through the development of cancers can be mediated by a diversity of endogenous and environmental stimuli. Active oxygen species and other free radicals have long been known to be mutagenic; further, these agents have more recently emerged as mediators of the other phenotypic and genotypic changes that lead from mutation to neoplasia. Free radical production is ubiquitous in all respiring organisms, and is enhanced in many disease states, by carcinogen exposure, and under conditions of stress. Free radicals may therefore contribute widely to cancer development in humans. This review explores the molecular mechanisms through which free radicals can participate in the carcinogenic process. SN - 0007-1420 UR - https://www.unboundmedicine.com/medline/citation/8221020/Oxidative_mechanisms_in_carcinogenesis_ L2 - https://academic.oup.com/bmb/article-lookup/doi/10.1093/oxfordjournals.bmb.a072628 DB - PRIME DP - Unbound Medicine ER -