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[The effect of glutamine on cholestasis caused by total parenteral nutrition].
Zhonghua Wai Ke Za Zhi. 1993 Feb; 31(2):94-6.ZW

Abstract

Glutamine is a tissue specific nutrient but not contained in standard TPN solution. To evaluate the effect of L-glutamine on TPN-induced cholestasis, 40 female Wistar rats were divided randomly into control or experimental groups. The rats were further subgrouped according to the days of observation and all received isocaloric (1008kJ.kg-1 x d-1) and isonitrogenous (1.22g.kg-1 x d-1) TPN support. 1% L-glutamine was given to the experimental group. Serum total bilirubin, albumin, lipoprotein X, r-GT, AKP and TG were determined on the day before study and 6th or 10th day after TPN. Before sacrifice, liver biopsies were taken for both light and electronic microscopic examinations, and the specimen of small intestine token for histologic evaluation. The results showed that the addition of glutamine to TPN solution can remarkably decrease the incidence, or ameliorate TPN induced cholestasis, and prevent small intestinal mucosal atrophy.

Authors+Show Affiliations

PLA General Hospital, Nanjing.

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

8223015

Citation

Yang, R R.. "[The Effect of Glutamine On Cholestasis Caused By Total Parenteral Nutrition]." Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery], vol. 31, no. 2, 1993, pp. 94-6.
Yang RR. [The effect of glutamine on cholestasis caused by total parenteral nutrition]. Zhonghua Wai Ke Za Zhi. 1993;31(2):94-6.
Yang, R. R. (1993). [The effect of glutamine on cholestasis caused by total parenteral nutrition]. Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery], 31(2), 94-6.
Yang RR. [The Effect of Glutamine On Cholestasis Caused By Total Parenteral Nutrition]. Zhonghua Wai Ke Za Zhi. 1993;31(2):94-6. PubMed PMID: 8223015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effect of glutamine on cholestasis caused by total parenteral nutrition]. A1 - Yang,R R, PY - 1993/2/1/pubmed PY - 1993/2/1/medline PY - 1993/2/1/entrez SP - 94 EP - 6 JF - Zhonghua wai ke za zhi [Chinese journal of surgery] JO - Zhonghua Wai Ke Za Zhi VL - 31 IS - 2 N2 - Glutamine is a tissue specific nutrient but not contained in standard TPN solution. To evaluate the effect of L-glutamine on TPN-induced cholestasis, 40 female Wistar rats were divided randomly into control or experimental groups. The rats were further subgrouped according to the days of observation and all received isocaloric (1008kJ.kg-1 x d-1) and isonitrogenous (1.22g.kg-1 x d-1) TPN support. 1% L-glutamine was given to the experimental group. Serum total bilirubin, albumin, lipoprotein X, r-GT, AKP and TG were determined on the day before study and 6th or 10th day after TPN. Before sacrifice, liver biopsies were taken for both light and electronic microscopic examinations, and the specimen of small intestine token for histologic evaluation. The results showed that the addition of glutamine to TPN solution can remarkably decrease the incidence, or ameliorate TPN induced cholestasis, and prevent small intestinal mucosal atrophy. SN - 0529-5815 UR - https://www.unboundmedicine.com/medline/citation/8223015/[The_effect_of_glutamine_on_cholestasis_caused_by_total_parenteral_nutrition]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0529-5815&year=1993&vol=31&issue=2&fpage=94 DB - PRIME DP - Unbound Medicine ER -