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Effect of an orally administered sulfonylurea, glipizide, for treatment of diabetes mellitus in cats.
J Am Vet Med Assoc. 1993 Sep 15; 203(6):821-7.JA

Abstract

An orally administered sulfonylurea drug, glipizide, was evaluated for treatment of diabetes mellitus. Confirmation of diabetes was based on evidence of appropriate clinical signs, persistent hyperglycemia, and glucosuria. Glipizide (5 mg, PO, q 12 h) was administered to each cat. Sixteen cats were fed a commercial high-fiber diet and 4 cats were fed a commercial low-fiber diet. Insulin was not administered to any cat during the study. Each cat was evaluated 2, 4, 8, and 12 weeks after initiation of treatment. Three clinical responses to glipizide treatment were identified. Mean preprandial blood glucose concentration and mean blood glucose concentration during an 8-hour postprandial period decreased to < 200 mg/dl in 5 of 20 (25%) cats. In these 5 cats, glucosuria was no longer detected and clinical signs resolved by the 4-week reevaluation. Euglycemia was maintained after discontinuing glipizide treatment in 2 of these 5 cats. Glycemic control has been maintained in 2 of 5 of the responding cats for 5 and 7 months of glipizide treatment. One of 5 of the responding cats developed insulin-requiring diabetes mellitus after 6 months of glipizide treatment. Seven of 20 (35%) cats failed to respond to treatment. Mean preprandial blood glucose concentration and mean blood glucose concentration during an 8-hour postprandial period did not change from pretreatment values after 2 +/- 1 months; glucosuria persisted and clinical signs progressively worsened. Insulin treatment was required to establish glycemic control in these 7 cats. Eight of 20 (40%) cats partially responded to glipizide treatment.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Medicine, School of Veterinary Medicine, University of California, CA 95616.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8226235

Citation

Nelson, R W., et al. "Effect of an Orally Administered Sulfonylurea, Glipizide, for Treatment of Diabetes Mellitus in Cats." Journal of the American Veterinary Medical Association, vol. 203, no. 6, 1993, pp. 821-7.
Nelson RW, Feldman EC, Ford SL, et al. Effect of an orally administered sulfonylurea, glipizide, for treatment of diabetes mellitus in cats. J Am Vet Med Assoc. 1993;203(6):821-7.
Nelson, R. W., Feldman, E. C., Ford, S. L., & Roemer, O. P. (1993). Effect of an orally administered sulfonylurea, glipizide, for treatment of diabetes mellitus in cats. Journal of the American Veterinary Medical Association, 203(6), 821-7.
Nelson RW, et al. Effect of an Orally Administered Sulfonylurea, Glipizide, for Treatment of Diabetes Mellitus in Cats. J Am Vet Med Assoc. 1993 Sep 15;203(6):821-7. PubMed PMID: 8226235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of an orally administered sulfonylurea, glipizide, for treatment of diabetes mellitus in cats. AU - Nelson,R W, AU - Feldman,E C, AU - Ford,S L, AU - Roemer,O P, PY - 1993/9/15/pubmed PY - 1993/9/15/medline PY - 1993/9/15/entrez SP - 821 EP - 7 JF - Journal of the American Veterinary Medical Association JO - J Am Vet Med Assoc VL - 203 IS - 6 N2 - An orally administered sulfonylurea drug, glipizide, was evaluated for treatment of diabetes mellitus. Confirmation of diabetes was based on evidence of appropriate clinical signs, persistent hyperglycemia, and glucosuria. Glipizide (5 mg, PO, q 12 h) was administered to each cat. Sixteen cats were fed a commercial high-fiber diet and 4 cats were fed a commercial low-fiber diet. Insulin was not administered to any cat during the study. Each cat was evaluated 2, 4, 8, and 12 weeks after initiation of treatment. Three clinical responses to glipizide treatment were identified. Mean preprandial blood glucose concentration and mean blood glucose concentration during an 8-hour postprandial period decreased to < 200 mg/dl in 5 of 20 (25%) cats. In these 5 cats, glucosuria was no longer detected and clinical signs resolved by the 4-week reevaluation. Euglycemia was maintained after discontinuing glipizide treatment in 2 of these 5 cats. Glycemic control has been maintained in 2 of 5 of the responding cats for 5 and 7 months of glipizide treatment. One of 5 of the responding cats developed insulin-requiring diabetes mellitus after 6 months of glipizide treatment. Seven of 20 (35%) cats failed to respond to treatment. Mean preprandial blood glucose concentration and mean blood glucose concentration during an 8-hour postprandial period did not change from pretreatment values after 2 +/- 1 months; glucosuria persisted and clinical signs progressively worsened. Insulin treatment was required to establish glycemic control in these 7 cats. Eight of 20 (40%) cats partially responded to glipizide treatment.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0003-1488 UR - https://www.unboundmedicine.com/medline/citation/8226235/Effect_of_an_orally_administered_sulfonylurea_glipizide_for_treatment_of_diabetes_mellitus_in_cats_ DB - PRIME DP - Unbound Medicine ER -