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Long-term consequences of impaired regeneration on facial motoneurons in the C57BL/Ola mouse.
J Comp Neurol. 1993 Sep 22; 335(4):576-85.JC

Abstract

Peripheral nerves of the C57BL/Ola mouse mutant undergo markedly slowed Wallerian degeneration following injury. This is associated with impaired regeneration of both sensory and motor axons. Following a crush lesion of the facial nerve, there was no cell loss in facial nuclei of normal (C57BL/6J) adult mice, but 40% cell loss occurred in Ola mice and the survivors increased in size during the period when functional reinnervation was established. These results are interpreted as a result, first, of prolonged deprivation of target-derived trophic factor in the slowly regenerating Ola motoneurons and second, increased peripheral field size of the survivors. Within the regenerated facial nerve, there was marked heterogeneity of myelinated fibre size in Ola mice. Some Ola axons, both proximal and distal to the lesion site, had areas over twice as great as the largest 6J axons when measured 1 year following injury. A population of small diameter fibres, not observed in 6J nerves, persisted distal to the crush site in Ola nerves, and this was associated with an increase in the total number of myelinated axons in the distal nerve: on average, each parent Ola axon retained three persistent daughter axons. The delayed Wallerian degeneration in Ola mice not only impairs immediate axon regrowth, but also results in a breakdown of the normal mechanisms which regulate axon number and size in regenerating nerve.

Authors+Show Affiliations

Department of Physiology, Queen's University, Kingston, Ontario, Canada.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8227536

Citation

Chen, S, and M A. Bisby. "Long-term Consequences of Impaired Regeneration On Facial Motoneurons in the C57BL/Ola Mouse." The Journal of Comparative Neurology, vol. 335, no. 4, 1993, pp. 576-85.
Chen S, Bisby MA. Long-term consequences of impaired regeneration on facial motoneurons in the C57BL/Ola mouse. J Comp Neurol. 1993;335(4):576-85.
Chen, S., & Bisby, M. A. (1993). Long-term consequences of impaired regeneration on facial motoneurons in the C57BL/Ola mouse. The Journal of Comparative Neurology, 335(4), 576-85.
Chen S, Bisby MA. Long-term Consequences of Impaired Regeneration On Facial Motoneurons in the C57BL/Ola Mouse. J Comp Neurol. 1993 Sep 22;335(4):576-85. PubMed PMID: 8227536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term consequences of impaired regeneration on facial motoneurons in the C57BL/Ola mouse. AU - Chen,S, AU - Bisby,M A, PY - 1993/9/22/pubmed PY - 1993/9/22/medline PY - 1993/9/22/entrez SP - 576 EP - 85 JF - The Journal of comparative neurology JO - J Comp Neurol VL - 335 IS - 4 N2 - Peripheral nerves of the C57BL/Ola mouse mutant undergo markedly slowed Wallerian degeneration following injury. This is associated with impaired regeneration of both sensory and motor axons. Following a crush lesion of the facial nerve, there was no cell loss in facial nuclei of normal (C57BL/6J) adult mice, but 40% cell loss occurred in Ola mice and the survivors increased in size during the period when functional reinnervation was established. These results are interpreted as a result, first, of prolonged deprivation of target-derived trophic factor in the slowly regenerating Ola motoneurons and second, increased peripheral field size of the survivors. Within the regenerated facial nerve, there was marked heterogeneity of myelinated fibre size in Ola mice. Some Ola axons, both proximal and distal to the lesion site, had areas over twice as great as the largest 6J axons when measured 1 year following injury. A population of small diameter fibres, not observed in 6J nerves, persisted distal to the crush site in Ola nerves, and this was associated with an increase in the total number of myelinated axons in the distal nerve: on average, each parent Ola axon retained three persistent daughter axons. The delayed Wallerian degeneration in Ola mice not only impairs immediate axon regrowth, but also results in a breakdown of the normal mechanisms which regulate axon number and size in regenerating nerve. SN - 0021-9967 UR - https://www.unboundmedicine.com/medline/citation/8227536/Long_term_consequences_of_impaired_regeneration_on_facial_motoneurons_in_the_C57BL/Ola_mouse_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0021-9967&date=1993&volume=335&issue=4&spage=576 DB - PRIME DP - Unbound Medicine ER -