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Immunoglobulin M antibody response to measles virus following primary and secondary vaccination and natural virus infection.
J Med Virol. 1993 Sep; 41(1):44-8.JM

Abstract

The use of IgM antibody detection for the classification of the primary and secondary measles antibody response in persons following primary and secondary vaccination and natural measles virus infection was examined. Of 32 nonimmune children receiving primary measles vaccination, 31 (97%) developed IgM antibodies, consistent with a primary antibody response. Of 21 previously vaccinated children with low levels of preexisting IgG antibodies who responded to revaccination, none developed detectable IgM antibodies, whereas 33 of 35 (94%) with no detectable preexisting IgG antibodies developed an IgM response. Of a sample of 57 measles cases with a prior history of vaccination, 55 (96%) had detectable IgM antibodies. Of these, 30 (55%) were classified as having a primary antibody response and 25 (45%) a secondary antibody response based on differences in their ratios of IgM to IgG antibodies. Differences in the severity of clinical symptoms between these 2 groups were consistent with this classification scheme. These findings suggest that 1) an IgM response follows primary measles vaccination in the immunologically naive, 2) an IgM response is absent on revaccination of those previously immunized, and 3) an IgM response may follow clinical measles virus infection independent of prior immunization status.

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Authors+Show Affiliations

Erdman DD
Respiratory and Enterovirus Branch, Centers for Disease Control, Atlanta, GA 30333.
Heath JL
No affiliation info available
Watson JC
No affiliation info available
Markowitz LE
No affiliation info available
Bellini WJ
No affiliation info available

MeSH

AdolescentAdultAntibodies, ViralChildChild, PreschoolDrug CombinationsHumansImmunization, SecondaryImmunoglobulin GImmunoglobulin MInfantMeaslesMeasles VaccineMeasles virusMeasles-Mumps-Rubella VaccineMumps VaccineRubella VaccineVaccination

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8228936

Citation

Erdman, D D., et al. "Immunoglobulin M Antibody Response to Measles Virus Following Primary and Secondary Vaccination and Natural Virus Infection." Journal of Medical Virology, vol. 41, no. 1, 1993, pp. 44-8.
Erdman DD, Heath JL, Watson JC, et al. Immunoglobulin M antibody response to measles virus following primary and secondary vaccination and natural virus infection. J Med Virol. 1993;41(1):44-8.
Erdman, D. D., Heath, J. L., Watson, J. C., Markowitz, L. E., & Bellini, W. J. (1993). Immunoglobulin M antibody response to measles virus following primary and secondary vaccination and natural virus infection. Journal of Medical Virology, 41(1), 44-8.
Erdman DD, et al. Immunoglobulin M Antibody Response to Measles Virus Following Primary and Secondary Vaccination and Natural Virus Infection. J Med Virol. 1993;41(1):44-8. PubMed PMID: 8228936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoglobulin M antibody response to measles virus following primary and secondary vaccination and natural virus infection. AU - Erdman,D D, AU - Heath,J L, AU - Watson,J C, AU - Markowitz,L E, AU - Bellini,W J, PY - 1993/9/1/pubmed PY - 1993/9/1/medline PY - 1993/9/1/entrez SP - 44 EP - 8 JF - Journal of medical virology JO - J Med Virol VL - 41 IS - 1 N2 - The use of IgM antibody detection for the classification of the primary and secondary measles antibody response in persons following primary and secondary vaccination and natural measles virus infection was examined. Of 32 nonimmune children receiving primary measles vaccination, 31 (97%) developed IgM antibodies, consistent with a primary antibody response. Of 21 previously vaccinated children with low levels of preexisting IgG antibodies who responded to revaccination, none developed detectable IgM antibodies, whereas 33 of 35 (94%) with no detectable preexisting IgG antibodies developed an IgM response. Of a sample of 57 measles cases with a prior history of vaccination, 55 (96%) had detectable IgM antibodies. Of these, 30 (55%) were classified as having a primary antibody response and 25 (45%) a secondary antibody response based on differences in their ratios of IgM to IgG antibodies. Differences in the severity of clinical symptoms between these 2 groups were consistent with this classification scheme. These findings suggest that 1) an IgM response follows primary measles vaccination in the immunologically naive, 2) an IgM response is absent on revaccination of those previously immunized, and 3) an IgM response may follow clinical measles virus infection independent of prior immunization status. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/8228936/Immunoglobulin_M_antibody_response_to_measles_virus_following_primary_and_secondary_vaccination_and_natural_virus_infection_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0146-6615&date=1993&volume=41&issue=1&spage=44 DB - PRIME DP - Unbound Medicine ER -