Abstract
Although bullous amyloid lesions are very rare, the cutaneous lesions of this type can be a crucial manifestation of plasma cell dyscrasia. [Case Report] A 66-year-old man with a six-year history of multiple myeloma (IgG-lambda, lambda-type Bence Jones proteins) was admitted to the hospital because of hemorrhagic bullous lesions of the skin, chronic diarrhea and general malaise. A diagnosis of myeloma-associated amyloidosis with renal failure was made. One month later, he died as a consequence of progressive renal failure and systemic amyloidosis. A postmortem examination revealed myelomatous infiltrations (bone marrow and kidneys) and widespread amyloid deposits (skin, heart, lungs, kidneys, liver and intestine). The histologic examination of a bullous lesion showed amyloid deposits with formation of an intradermal blister.
TY - JOUR
T1 - [Bullous amyloidosis].
A1 - Kanoh,T,
PY - 1993/9/1/pubmed
PY - 1993/9/1/medline
PY - 1993/9/1/entrez
SP - 1050
EP - 2
JF - [Rinsho ketsueki] The Japanese journal of clinical hematology
JO - Rinsho Ketsueki
VL - 34
IS - 9
N2 - Although bullous amyloid lesions are very rare, the cutaneous lesions of this type can be a crucial manifestation of plasma cell dyscrasia. [Case Report] A 66-year-old man with a six-year history of multiple myeloma (IgG-lambda, lambda-type Bence Jones proteins) was admitted to the hospital because of hemorrhagic bullous lesions of the skin, chronic diarrhea and general malaise. A diagnosis of myeloma-associated amyloidosis with renal failure was made. One month later, he died as a consequence of progressive renal failure and systemic amyloidosis. A postmortem examination revealed myelomatous infiltrations (bone marrow and kidneys) and widespread amyloid deposits (skin, heart, lungs, kidneys, liver and intestine). The histologic examination of a bullous lesion showed amyloid deposits with formation of an intradermal blister.
SN - 0485-1439
UR - https://www.unboundmedicine.com/medline/citation/8230750/[Bullous_amyloidosis]_
L2 - http://www.diseaseinfosearch.org/result/380
DB - PRIME
DP - Unbound Medicine
ER -