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Action of cisapride on rat colonic secretion.
Naunyn Schmiedebergs Arch Pharmacol. 1993 Sep; 348(3):319-24.NS

Abstract

The stimulating effect of cisapride on the motility of the digestive tract is well known. However, there are only a few studies on the influence of this drug on the absorptive or secretory activity of the colonic mucosa. In the present study, the ability of cisapride to alter the mural transport of water and electrolytes in the colon and its effects on mucus secretion and albumin permeation were studied. The effects of cisapride on the rat colon in vivo were studied under different conditions, by means of an instillation of sodium acetate solution at pH 6.9, which induced absorption of water and electrolytes, and in two models of colonic secretion, one employing the instillation of an acetic acid solution at pH 2.9 and the other, an intravenous infusion of 5-hydroxytryptamine (serotonin) 45 micrograms.kg-1.min-1 together with intracolonic instillation of sodium acetate. Cisapride (i.v.), at a dose of 0.32 mg.kg-1, in rats whose colon was instilled with sodium acetate (pH 6.9) induced an increase in sodium absorption and a reduction in water absorption. Cisapride (i.v.), at doses of 0.32, 0.64 and 1.0 mg.kg-1, inhibited the secretion of water, Na+, Cl-, and mucus and the permeation of albumin induced by acetic acid instillation or by serotonin infusion. It is concluded that the effect of cisapride on the colonic mucosa varies in accordance with the functional mucosal conditions and that this action may be of clinical importance.

Authors+Show Affiliations

Instituto de Gastroenterologia Dr. Jorge Perez Companc, Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8232608

Citation

Bandi, J C., et al. "Action of Cisapride On Rat Colonic Secretion." Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 348, no. 3, 1993, pp. 319-24.
Bandi JC, Rosembeck G, De Paula JA, et al. Action of cisapride on rat colonic secretion. Naunyn Schmiedebergs Arch Pharmacol. 1993;348(3):319-24.
Bandi, J. C., Rosembeck, G., De Paula, J. A., Ledesma de Paolo, M. I., Celener, D., Gravelle, P. C., & Bustos Fernandez, L. (1993). Action of cisapride on rat colonic secretion. Naunyn-Schmiedeberg's Archives of Pharmacology, 348(3), 319-24.
Bandi JC, et al. Action of Cisapride On Rat Colonic Secretion. Naunyn Schmiedebergs Arch Pharmacol. 1993;348(3):319-24. PubMed PMID: 8232608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Action of cisapride on rat colonic secretion. AU - Bandi,J C, AU - Rosembeck,G, AU - De Paula,J A, AU - Ledesma de Paolo,M I, AU - Celener,D, AU - Gravelle,P C, AU - Bustos Fernandez,L, PY - 1993/9/1/pubmed PY - 1993/9/1/medline PY - 1993/9/1/entrez SP - 319 EP - 24 JF - Naunyn-Schmiedeberg's archives of pharmacology JO - Naunyn Schmiedebergs Arch. Pharmacol. VL - 348 IS - 3 N2 - The stimulating effect of cisapride on the motility of the digestive tract is well known. However, there are only a few studies on the influence of this drug on the absorptive or secretory activity of the colonic mucosa. In the present study, the ability of cisapride to alter the mural transport of water and electrolytes in the colon and its effects on mucus secretion and albumin permeation were studied. The effects of cisapride on the rat colon in vivo were studied under different conditions, by means of an instillation of sodium acetate solution at pH 6.9, which induced absorption of water and electrolytes, and in two models of colonic secretion, one employing the instillation of an acetic acid solution at pH 2.9 and the other, an intravenous infusion of 5-hydroxytryptamine (serotonin) 45 micrograms.kg-1.min-1 together with intracolonic instillation of sodium acetate. Cisapride (i.v.), at a dose of 0.32 mg.kg-1, in rats whose colon was instilled with sodium acetate (pH 6.9) induced an increase in sodium absorption and a reduction in water absorption. Cisapride (i.v.), at doses of 0.32, 0.64 and 1.0 mg.kg-1, inhibited the secretion of water, Na+, Cl-, and mucus and the permeation of albumin induced by acetic acid instillation or by serotonin infusion. It is concluded that the effect of cisapride on the colonic mucosa varies in accordance with the functional mucosal conditions and that this action may be of clinical importance. SN - 0028-1298 UR - https://www.unboundmedicine.com/medline/citation/8232608/Action_of_cisapride_on_rat_colonic_secretion_ DB - PRIME DP - Unbound Medicine ER -