Tags

Type your tag names separated by a space and hit enter

Macrophage colony-stimulating factor as a tumor marker for epithelial ovarian cancer.
Obstet Gynecol. 1993 Dec; 82(6):946-50.OG

Abstract

OBJECTIVE

To determine the serum level of macrophage colony-stimulating factor in ovarian cancer patients in order to evaluate its role as a marker for ovarian cancer.

METHODS

Serum macrophage colony-stimulating factor levels were assayed in 69 patients with epithelial ovarian cancer, 55 with benign ovarian tumors, and 634 healthy individuals, including 398 women, using an enzyme-linked immunosorbent assay.

RESULTS

The average serum macrophage colony-stimulating factor level was 754.4 +/- 153.9 U/mL in healthy females; 1056 U/mL (mean plus 1.96 standard deviations) was considered to be the upper limit of normal. Serum macrophage colony-stimulating factor levels were significantly elevated in patients with ovarian cancer (average 1460.5 +/- 1006.2 U/mL; P < .001) and exceeded 1056 U/mL in 42 of the 69 patients with ovarian cancer (61%). No differences in levels were observed among the histologic types. No definite relationship was found between serum levels of macrophage colony-stimulating factor and those of CA 125. We found that 96% of the patients with ovarian cancer had high serum levels of macrophage colony-stimulating factor and/or CA 125 values. There was no significant difference in the levels of macrophage colony-stimulating factor between patients with benign ovarian tumors and healthy controls. Only 7.3% of the group with benign tumors had levels exceeding 1056 U/mL.

CONCLUSION

Macrophage colony-stimulating factor is a marker for ovarian cancer. Determination of serum levels can be useful in detecting ovarian cancer, particularly in combination with CA 125.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Jichi Medical School, School of Medicine, Tochigi, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8233270

Citation

Suzuki, M, et al. "Macrophage Colony-stimulating Factor as a Tumor Marker for Epithelial Ovarian Cancer." Obstetrics and Gynecology, vol. 82, no. 6, 1993, pp. 946-50.
Suzuki M, Ohwada M, Aida I, et al. Macrophage colony-stimulating factor as a tumor marker for epithelial ovarian cancer. Obstet Gynecol. 1993;82(6):946-50.
Suzuki, M., Ohwada, M., Aida, I., Tamada, T., Hanamura, T., & Nagatomo, M. (1993). Macrophage colony-stimulating factor as a tumor marker for epithelial ovarian cancer. Obstetrics and Gynecology, 82(6), 946-50.
Suzuki M, et al. Macrophage Colony-stimulating Factor as a Tumor Marker for Epithelial Ovarian Cancer. Obstet Gynecol. 1993;82(6):946-50. PubMed PMID: 8233270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macrophage colony-stimulating factor as a tumor marker for epithelial ovarian cancer. AU - Suzuki,M, AU - Ohwada,M, AU - Aida,I, AU - Tamada,T, AU - Hanamura,T, AU - Nagatomo,M, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 946 EP - 50 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 82 IS - 6 N2 - OBJECTIVE: To determine the serum level of macrophage colony-stimulating factor in ovarian cancer patients in order to evaluate its role as a marker for ovarian cancer. METHODS: Serum macrophage colony-stimulating factor levels were assayed in 69 patients with epithelial ovarian cancer, 55 with benign ovarian tumors, and 634 healthy individuals, including 398 women, using an enzyme-linked immunosorbent assay. RESULTS: The average serum macrophage colony-stimulating factor level was 754.4 +/- 153.9 U/mL in healthy females; 1056 U/mL (mean plus 1.96 standard deviations) was considered to be the upper limit of normal. Serum macrophage colony-stimulating factor levels were significantly elevated in patients with ovarian cancer (average 1460.5 +/- 1006.2 U/mL; P < .001) and exceeded 1056 U/mL in 42 of the 69 patients with ovarian cancer (61%). No differences in levels were observed among the histologic types. No definite relationship was found between serum levels of macrophage colony-stimulating factor and those of CA 125. We found that 96% of the patients with ovarian cancer had high serum levels of macrophage colony-stimulating factor and/or CA 125 values. There was no significant difference in the levels of macrophage colony-stimulating factor between patients with benign ovarian tumors and healthy controls. Only 7.3% of the group with benign tumors had levels exceeding 1056 U/mL. CONCLUSION: Macrophage colony-stimulating factor is a marker for ovarian cancer. Determination of serum levels can be useful in detecting ovarian cancer, particularly in combination with CA 125. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/8233270/Macrophage_colony_stimulating_factor_as_a_tumor_marker_for_epithelial_ovarian_cancer_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=8233270.ui DB - PRIME DP - Unbound Medicine ER -