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[Anemias due to disorder of folate, vitamin B12 and transcobalamin metabolism].
Rev Prat. 1993 Jun 01; 43(11):1358-63.RP

Abstract

Macrocytic megaloblastic anemia is the most typical but the latest sign of a cobalamin (vitamin B12) and/or folic acid deficiency or of a congenital abnormality of cobalamin and folate metabolism. Macrocytosis in blood and megaloblastosis in bone marrow are the morphological features of a disturbance in cell division related to a defect in DNA biosynthesis. Macrocytosis without anemia, normocytic normochronic anemia with a low reticulocyte cell count or microcytic hypochromic anemia in case of associated iron deficiency do not exclude a vitamin deficiency. Neurological or psychiatric disorders and immune abnormalities have been reported in patients with vitamin B12 or folate deficiencies or in children with congenital abnormalities of these 2 vitamins; such manifestations may even occur without anemia.

Authors+Show Affiliations

Laboratoire central d'hématologie-immunologie, hôpital Henri-Mondor, Créteil.

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

8235383

Citation

Zittoun, J. "[Anemias Due to Disorder of Folate, Vitamin B12 and Transcobalamin Metabolism]." La Revue Du Praticien, vol. 43, no. 11, 1993, pp. 1358-63.
Zittoun J. [Anemias due to disorder of folate, vitamin B12 and transcobalamin metabolism]. Rev Prat. 1993;43(11):1358-63.
Zittoun, J. (1993). [Anemias due to disorder of folate, vitamin B12 and transcobalamin metabolism]. La Revue Du Praticien, 43(11), 1358-63.
Zittoun J. [Anemias Due to Disorder of Folate, Vitamin B12 and Transcobalamin Metabolism]. Rev Prat. 1993 Jun 1;43(11):1358-63. PubMed PMID: 8235383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Anemias due to disorder of folate, vitamin B12 and transcobalamin metabolism]. A1 - Zittoun,J, PY - 1993/6/1/pubmed PY - 1993/6/1/medline PY - 1993/6/1/entrez SP - 1358 EP - 63 JF - La Revue du praticien JO - Rev Prat VL - 43 IS - 11 N2 - Macrocytic megaloblastic anemia is the most typical but the latest sign of a cobalamin (vitamin B12) and/or folic acid deficiency or of a congenital abnormality of cobalamin and folate metabolism. Macrocytosis in blood and megaloblastosis in bone marrow are the morphological features of a disturbance in cell division related to a defect in DNA biosynthesis. Macrocytosis without anemia, normocytic normochronic anemia with a low reticulocyte cell count or microcytic hypochromic anemia in case of associated iron deficiency do not exclude a vitamin deficiency. Neurological or psychiatric disorders and immune abnormalities have been reported in patients with vitamin B12 or folate deficiencies or in children with congenital abnormalities of these 2 vitamins; such manifestations may even occur without anemia. SN - 0035-2640 UR - https://www.unboundmedicine.com/medline/citation/8235383/[Anemias_due_to_disorder_of_folate_vitamin_B12_and_transcobalamin_metabolism]_ L2 - http://www.diseaseinfosearch.org/result/441 DB - PRIME DP - Unbound Medicine ER -