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Light chain disease: report of an atypical case.
South Med J. 1976 Sep; 69(9):1216-7.SM

Abstract

A 50-year-old black man had the signs and symptoms of severe anemia. His bone marrow contained sheets of primitive cells that could only be conclusively identified as being of plasmacytic origin by electron microscopy. These cells produced only a small quantity of kappa light chain but did fluoresce when stained with immunofluorescent antikappa stain. His initial response to chemotherapy was dramatic, but after eight months his condition was refractory to all further attempts at treatment. This case supports the observation of Hobbs that patients with Bence-Jones myeloma may have a poorer prognosis than those with otherwise typical IgG or IgA myeloma.

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Authors

Kardinal CG
No affiliation info available
Komorowski R
No affiliation info available

MeSH

AutopsyBone Marrow ExaminationHumansImmunoglobulin Light ChainsImmunoglobulin kappa-ChainsLiverMaleMiddle AgedMultiple MyelomaMyeloma ProteinsPlasma CellsPrognosis

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

823646

Citation

Kardinal, C G., and R Komorowski. "Light Chain Disease: Report of an Atypical Case." Southern Medical Journal, vol. 69, no. 9, 1976, pp. 1216-7.
Kardinal CG, Komorowski R. Light chain disease: report of an atypical case. South Med J. 1976;69(9):1216-7.
Kardinal, C. G., & Komorowski, R. (1976). Light chain disease: report of an atypical case. Southern Medical Journal, 69(9), 1216-7.
Kardinal CG, Komorowski R. Light Chain Disease: Report of an Atypical Case. South Med J. 1976;69(9):1216-7. PubMed PMID: 823646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Light chain disease: report of an atypical case. AU - Kardinal,C G, AU - Komorowski,R, PY - 1976/9/1/pubmed PY - 1976/9/1/medline PY - 1976/9/1/entrez SP - 1216 EP - 7 JF - Southern medical journal JO - South Med J VL - 69 IS - 9 N2 - A 50-year-old black man had the signs and symptoms of severe anemia. His bone marrow contained sheets of primitive cells that could only be conclusively identified as being of plasmacytic origin by electron microscopy. These cells produced only a small quantity of kappa light chain but did fluoresce when stained with immunofluorescent antikappa stain. His initial response to chemotherapy was dramatic, but after eight months his condition was refractory to all further attempts at treatment. This case supports the observation of Hobbs that patients with Bence-Jones myeloma may have a poorer prognosis than those with otherwise typical IgG or IgA myeloma. SN - 0038-4348 UR - https://www.unboundmedicine.com/medline/citation/823646/Light_chain_disease:_report_of_an_atypical_case_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=823646.ui DB - PRIME DP - Unbound Medicine ER -