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Seven-day pyridostigmine administration and thermoregulation during rest and exercise in dry heat.
Aviat Space Environ Med 1993; 64(10):905-11AS

Abstract

Seven men participated in a double-blind study of effects of multiple-dose oral pyridostigmine bromide (PB) on physiological responses to 4-h heat stress tests (HST's) in a hot dry environment, 42 degrees C, 20% relative humidity. Subjects underwent 2 7-d series of tests, separated by 72 h, taking 30 mg PB every 8 h in one series, and placebo in the other. Each HST began right after the 0800 dose of PB or placebo. Subjects drank ad libitum during each HST, and performed two 55-min treadmill walks at about 40% VO2max during the last 2 h. Inhibition of red cell cholinesterase at the start of exercise averaged 30.0% in subjects taking PB, and did not differ significantly among HST's with PB. PB increased sweating and evaporative water loss by about 4%, and lowered chest skin temperature during exercise by 0.7 degrees C; but it had no significant effect on rectal temperature, other skin temperatures, O2 uptake, or fluid balance. PB alone had no significant effect on heart rate (HR), but had a significant interaction with day: although PB had essentially no effect on HR in the 1st HST, its effect increased progressively so that HR during exercise in the 4th HST was 8 beats.min-1 lower with PB. Multiple-dose PB had only slight effects on responses to moderate exercise-heat stress beyond those described after single-dose PB, and we found no adverse effects of multiple-dose PB administration.

Authors+Show Affiliations

U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760-5007.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8240194

Citation

Wenger, B, et al. "Seven-day Pyridostigmine Administration and Thermoregulation During Rest and Exercise in Dry Heat." Aviation, Space, and Environmental Medicine, vol. 64, no. 10, 1993, pp. 905-11.
Wenger B, Quigley MD, Kolka MA. Seven-day pyridostigmine administration and thermoregulation during rest and exercise in dry heat. Aviat Space Environ Med. 1993;64(10):905-11.
Wenger, B., Quigley, M. D., & Kolka, M. A. (1993). Seven-day pyridostigmine administration and thermoregulation during rest and exercise in dry heat. Aviation, Space, and Environmental Medicine, 64(10), pp. 905-11.
Wenger B, Quigley MD, Kolka MA. Seven-day Pyridostigmine Administration and Thermoregulation During Rest and Exercise in Dry Heat. Aviat Space Environ Med. 1993;64(10):905-11. PubMed PMID: 8240194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seven-day pyridostigmine administration and thermoregulation during rest and exercise in dry heat. AU - Wenger,B, AU - Quigley,M D, AU - Kolka,M A, PY - 1993/10/1/pubmed PY - 1993/10/1/medline PY - 1993/10/1/entrez SP - 905 EP - 11 JF - Aviation, space, and environmental medicine JO - Aviat Space Environ Med VL - 64 IS - 10 N2 - Seven men participated in a double-blind study of effects of multiple-dose oral pyridostigmine bromide (PB) on physiological responses to 4-h heat stress tests (HST's) in a hot dry environment, 42 degrees C, 20% relative humidity. Subjects underwent 2 7-d series of tests, separated by 72 h, taking 30 mg PB every 8 h in one series, and placebo in the other. Each HST began right after the 0800 dose of PB or placebo. Subjects drank ad libitum during each HST, and performed two 55-min treadmill walks at about 40% VO2max during the last 2 h. Inhibition of red cell cholinesterase at the start of exercise averaged 30.0% in subjects taking PB, and did not differ significantly among HST's with PB. PB increased sweating and evaporative water loss by about 4%, and lowered chest skin temperature during exercise by 0.7 degrees C; but it had no significant effect on rectal temperature, other skin temperatures, O2 uptake, or fluid balance. PB alone had no significant effect on heart rate (HR), but had a significant interaction with day: although PB had essentially no effect on HR in the 1st HST, its effect increased progressively so that HR during exercise in the 4th HST was 8 beats.min-1 lower with PB. Multiple-dose PB had only slight effects on responses to moderate exercise-heat stress beyond those described after single-dose PB, and we found no adverse effects of multiple-dose PB administration. SN - 0095-6562 UR - https://www.unboundmedicine.com/medline/citation/8240194/Seven_day_pyridostigmine_administration_and_thermoregulation_during_rest_and_exercise_in_dry_heat_ DB - PRIME DP - Unbound Medicine ER -