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Seven-day pyridostigmine administration and thermoregulation during rest and exercise in dry heat.

Abstract

Seven men participated in a double-blind study of effects of multiple-dose oral pyridostigmine bromide (PB) on physiological responses to 4-h heat stress tests (HST's) in a hot dry environment, 42 degrees C, 20% relative humidity. Subjects underwent 2 7-d series of tests, separated by 72 h, taking 30 mg PB every 8 h in one series, and placebo in the other. Each HST began right after the 0800 dose of PB or placebo. Subjects drank ad libitum during each HST, and performed two 55-min treadmill walks at about 40% VO2max during the last 2 h. Inhibition of red cell cholinesterase at the start of exercise averaged 30.0% in subjects taking PB, and did not differ significantly among HST's with PB. PB increased sweating and evaporative water loss by about 4%, and lowered chest skin temperature during exercise by 0.7 degrees C; but it had no significant effect on rectal temperature, other skin temperatures, O2 uptake, or fluid balance. PB alone had no significant effect on heart rate (HR), but had a significant interaction with day: although PB had essentially no effect on HR in the 1st HST, its effect increased progressively so that HR during exercise in the 4th HST was 8 beats.min-1 lower with PB. Multiple-dose PB had only slight effects on responses to moderate exercise-heat stress beyond those described after single-dose PB, and we found no adverse effects of multiple-dose PB administration.

Authors+Show Affiliations

,

U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760-5007.

,

Source

MeSH

Administration, Oral
Adult
Body Temperature
Body Temperature Regulation
Cholinesterases
Double-Blind Method
Erythrocytes
Exercise Test
Heart Rate
Hot Temperature
Humans
Humidity
Male
Physical Exertion
Pyridostigmine Bromide
Rest
Weight Loss

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8240194

Citation

Wenger, B, et al. "Seven-day Pyridostigmine Administration and Thermoregulation During Rest and Exercise in Dry Heat." Aviation, Space, and Environmental Medicine, vol. 64, no. 10, 1993, pp. 905-11.
Wenger B, Quigley MD, Kolka MA. Seven-day pyridostigmine administration and thermoregulation during rest and exercise in dry heat. Aviat Space Environ Med. 1993;64(10):905-11.
Wenger, B., Quigley, M. D., & Kolka, M. A. (1993). Seven-day pyridostigmine administration and thermoregulation during rest and exercise in dry heat. Aviation, Space, and Environmental Medicine, 64(10), pp. 905-11.
Wenger B, Quigley MD, Kolka MA. Seven-day Pyridostigmine Administration and Thermoregulation During Rest and Exercise in Dry Heat. Aviat Space Environ Med. 1993;64(10):905-11. PubMed PMID: 8240194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seven-day pyridostigmine administration and thermoregulation during rest and exercise in dry heat. AU - Wenger,B, AU - Quigley,M D, AU - Kolka,M A, PY - 1993/10/1/pubmed PY - 1993/10/1/medline PY - 1993/10/1/entrez SP - 905 EP - 11 JF - Aviation, space, and environmental medicine JO - Aviat Space Environ Med VL - 64 IS - 10 N2 - Seven men participated in a double-blind study of effects of multiple-dose oral pyridostigmine bromide (PB) on physiological responses to 4-h heat stress tests (HST's) in a hot dry environment, 42 degrees C, 20% relative humidity. Subjects underwent 2 7-d series of tests, separated by 72 h, taking 30 mg PB every 8 h in one series, and placebo in the other. Each HST began right after the 0800 dose of PB or placebo. Subjects drank ad libitum during each HST, and performed two 55-min treadmill walks at about 40% VO2max during the last 2 h. Inhibition of red cell cholinesterase at the start of exercise averaged 30.0% in subjects taking PB, and did not differ significantly among HST's with PB. PB increased sweating and evaporative water loss by about 4%, and lowered chest skin temperature during exercise by 0.7 degrees C; but it had no significant effect on rectal temperature, other skin temperatures, O2 uptake, or fluid balance. PB alone had no significant effect on heart rate (HR), but had a significant interaction with day: although PB had essentially no effect on HR in the 1st HST, its effect increased progressively so that HR during exercise in the 4th HST was 8 beats.min-1 lower with PB. Multiple-dose PB had only slight effects on responses to moderate exercise-heat stress beyond those described after single-dose PB, and we found no adverse effects of multiple-dose PB administration. SN - 0095-6562 UR - https://www.unboundmedicine.com/medline/citation/8240194/Seven_day_pyridostigmine_administration_and_thermoregulation_during_rest_and_exercise_in_dry_heat_ DB - PRIME DP - Unbound Medicine ER -