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Influence of probucol on enhanced LDL oxidation after fish oil treatment of hypertriglyceridemic patients.
Arterioscler Thromb. 1993 Dec; 13(12):1790-7.AT

Abstract

The susceptibility of low-density lipoprotein (LDL) to oxidation was studied in hypertriglyceridemic men (5 with type III and 5 with type IV) at baseline on a low-saturated-fat, low-cholesterol diet, after 6 weeks of dietary supplementation with fish oil (Promega, 12 g/d), and after 6 weeks of fish oil combined with probucol (500 mg BID). The relative content of n-3 polyunsaturated fatty acids in plasma and LDL was increased during the two treatment periods, and a low alpha-tocopherol to n-3 polyunsaturated fatty acids ratio was observed. Plasma thiobarbituric acid-reactive substances (TBARS) levels were unchanged after 6 weeks of fish oil, but the ratio of lipid peroxides to the reduced triglyceride (TG) levels (MDA:TG) was significantly higher (P < .01). Addition of probucol lowered both absolute levels of TBARS (P < .01) and the MDA to TG ratio (P < .001). The susceptibility of LDL to Cu(2+)-catalyzed oxidation was evaluated over a 5-hour time course by determining TBARS formation, free amino group levels, and changes in LDL electrophoretic mobility. TBARS levels that were higher in native LDL (1.019 < d < 1.050 g/mL) after 6 weeks of fish oil than at baseline (P < .01) were reduced 52.3 +/- 11.3% by the addition of probucol (P < .001). With fish oil alone, TBARS production after exposure of LDL to Cu2+ for 5 hours was increased 17.0 +/- 5.8% compared with corresponding baseline values (P < .001), whereas a 64.1 +/- 14.3% reduction from the previous period was observed with fish oil + probucol (P < .001).(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Québec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8241099

Citation

Lussier-Cacan, S, et al. "Influence of Probucol On Enhanced LDL Oxidation After Fish Oil Treatment of Hypertriglyceridemic Patients." Arteriosclerosis and Thrombosis : a Journal of Vascular Biology, vol. 13, no. 12, 1993, pp. 1790-7.
Lussier-Cacan S, Dubreuil-Quidoz S, Roederer G, et al. Influence of probucol on enhanced LDL oxidation after fish oil treatment of hypertriglyceridemic patients. Arterioscler Thromb. 1993;13(12):1790-7.
Lussier-Cacan, S., Dubreuil-Quidoz, S., Roederer, G., Leboeuf, N., Boulet, L., de Langavant, G. C., Davignon, J., & Naruszewicz, M. (1993). Influence of probucol on enhanced LDL oxidation after fish oil treatment of hypertriglyceridemic patients. Arteriosclerosis and Thrombosis : a Journal of Vascular Biology, 13(12), 1790-7.
Lussier-Cacan S, et al. Influence of Probucol On Enhanced LDL Oxidation After Fish Oil Treatment of Hypertriglyceridemic Patients. Arterioscler Thromb. 1993;13(12):1790-7. PubMed PMID: 8241099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of probucol on enhanced LDL oxidation after fish oil treatment of hypertriglyceridemic patients. AU - Lussier-Cacan,S, AU - Dubreuil-Quidoz,S, AU - Roederer,G, AU - Leboeuf,N, AU - Boulet,L, AU - de Langavant,G C, AU - Davignon,J, AU - Naruszewicz,M, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 1790 EP - 7 JF - Arteriosclerosis and thrombosis : a journal of vascular biology JO - Arterioscler Thromb VL - 13 IS - 12 N2 - The susceptibility of low-density lipoprotein (LDL) to oxidation was studied in hypertriglyceridemic men (5 with type III and 5 with type IV) at baseline on a low-saturated-fat, low-cholesterol diet, after 6 weeks of dietary supplementation with fish oil (Promega, 12 g/d), and after 6 weeks of fish oil combined with probucol (500 mg BID). The relative content of n-3 polyunsaturated fatty acids in plasma and LDL was increased during the two treatment periods, and a low alpha-tocopherol to n-3 polyunsaturated fatty acids ratio was observed. Plasma thiobarbituric acid-reactive substances (TBARS) levels were unchanged after 6 weeks of fish oil, but the ratio of lipid peroxides to the reduced triglyceride (TG) levels (MDA:TG) was significantly higher (P < .01). Addition of probucol lowered both absolute levels of TBARS (P < .01) and the MDA to TG ratio (P < .001). The susceptibility of LDL to Cu(2+)-catalyzed oxidation was evaluated over a 5-hour time course by determining TBARS formation, free amino group levels, and changes in LDL electrophoretic mobility. TBARS levels that were higher in native LDL (1.019 < d < 1.050 g/mL) after 6 weeks of fish oil than at baseline (P < .01) were reduced 52.3 +/- 11.3% by the addition of probucol (P < .001). With fish oil alone, TBARS production after exposure of LDL to Cu2+ for 5 hours was increased 17.0 +/- 5.8% compared with corresponding baseline values (P < .001), whereas a 64.1 +/- 14.3% reduction from the previous period was observed with fish oil + probucol (P < .001).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 1049-8834 UR - https://www.unboundmedicine.com/medline/citation/8241099/Influence_of_probucol_on_enhanced_LDL_oxidation_after_fish_oil_treatment_of_hypertriglyceridemic_patients_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=8241099.ui DB - PRIME DP - Unbound Medicine ER -