TY - JOUR T1 - The effect of a natural high-fibre diet on faecal and biliary bile acids, faecal pH and whole-gut transit time in man. A controlled study. AU - Nagengast,F M, AU - van den Ban,G, AU - Ploemen,J P, AU - Leenen,R, AU - Zock,P L, AU - Katan,M B, AU - Hectors,M P, AU - de Haan,A F, AU - van Tongeren,J H, PY - 1993/9/1/pubmed PY - 1993/9/1/medline PY - 1993/9/1/entrez SP - 631 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 47 IS - 9 N2 - Dietary fibre possibly protects against colonic cancer by effects on bile acid metabolism. We investigated the effect of a natural high-fibre diet on secondary bile acid formation. Twelve healthy subjects on an habitual low-fibre diet (for 4 weeks) consumed a high-fibre menu for 10 weeks (experimental group). A control group of 10 subjects consumed their regular high-fibre diet during this period. Faecal and biliary acid composition, faecal weight, faecal pH and gut transit time were studied before and after 6 and 10 weeks of fibre addition. Changes in the experimental group were compared to changes in the control group. The concentration, but not the excretion, of the secondary faecal bile acids was reduced in the experimental group. Faecal weight increased, faecal pH dropped and gut transit time was not altered. The biliary deoxycholic acid content decreased and the cholic acid content increased after 6 weeks, but returned to baseline values after 10 weeks of fibre addition. This study shows that a natural high-fibre diet lowers secondary faecal bile acid concentration through an increase in stool weight. The 7 alpha-dehydroxylation of primary bile acids is probably not or only transiently inhibited. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/8243428/The_effect_of_a_natural_high_fibre_diet_on_faecal_and_biliary_bile_acids_faecal_pH_and_whole_gut_transit_time_in_man__A_controlled_study_ L2 - https://medlineplus.gov/dietaryfiber.html DB - PRIME DP - Unbound Medicine ER -