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Elevated glutathione S-transferase activity in erythrocytes from malnourished children.
Eur J Clin Nutr 1993; 47(9):658-65EJ

Abstract

Glutathione S-transferases (GSTs) are principally involved in detoxification. These enzymes can be induced by an increased flux of substrate, such as occurs during pro-oxidative stress or antioxidant deficiency. We tested the hypothesis that the postulated oxidative stress in severe malnutrition would result in induction of GSTs in erythrocytes. Erythrocyte GST activity towards 1-chloro-2,4-dinitrobenzene (CDNB) was measured in 271 malnourished children (22 undernourished; 92 marasmic; 82 kwashiorkor; 75 marasmic-kwashiorkor) and 48 healthy children. GST activity in the malnourished children was significantly higher than the control group (P < 0.01). The GST activity in the four classes of malnutrition did not differ. There was a weak relationship between GST activity and the height deficit, but not with the weight deficit, or the clinical features displayed by the children. The 11 children that died had a higher value than the survivors. There was no change in GST with anthropometric recovery. We conclude that erythrocyte GST has been induced in children with malnutrition. Induction of erythrocyte GST may be the result of exposure of the children to oxidative stress during the months prior to their presentation with severe malnutrition.

Authors+Show Affiliations

Tropical Metabolism Research Unit, University of the West Indies, Kingston, Jamaica.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8243432

Citation

Ramdath, D D., and M H. Golden. "Elevated Glutathione S-transferase Activity in Erythrocytes From Malnourished Children." European Journal of Clinical Nutrition, vol. 47, no. 9, 1993, pp. 658-65.
Ramdath DD, Golden MH. Elevated glutathione S-transferase activity in erythrocytes from malnourished children. Eur J Clin Nutr. 1993;47(9):658-65.
Ramdath, D. D., & Golden, M. H. (1993). Elevated glutathione S-transferase activity in erythrocytes from malnourished children. European Journal of Clinical Nutrition, 47(9), pp. 658-65.
Ramdath DD, Golden MH. Elevated Glutathione S-transferase Activity in Erythrocytes From Malnourished Children. Eur J Clin Nutr. 1993;47(9):658-65. PubMed PMID: 8243432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated glutathione S-transferase activity in erythrocytes from malnourished children. AU - Ramdath,D D, AU - Golden,M H, PY - 1993/9/1/pubmed PY - 1993/9/1/medline PY - 1993/9/1/entrez SP - 658 EP - 65 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 47 IS - 9 N2 - Glutathione S-transferases (GSTs) are principally involved in detoxification. These enzymes can be induced by an increased flux of substrate, such as occurs during pro-oxidative stress or antioxidant deficiency. We tested the hypothesis that the postulated oxidative stress in severe malnutrition would result in induction of GSTs in erythrocytes. Erythrocyte GST activity towards 1-chloro-2,4-dinitrobenzene (CDNB) was measured in 271 malnourished children (22 undernourished; 92 marasmic; 82 kwashiorkor; 75 marasmic-kwashiorkor) and 48 healthy children. GST activity in the malnourished children was significantly higher than the control group (P < 0.01). The GST activity in the four classes of malnutrition did not differ. There was a weak relationship between GST activity and the height deficit, but not with the weight deficit, or the clinical features displayed by the children. The 11 children that died had a higher value than the survivors. There was no change in GST with anthropometric recovery. We conclude that erythrocyte GST has been induced in children with malnutrition. Induction of erythrocyte GST may be the result of exposure of the children to oxidative stress during the months prior to their presentation with severe malnutrition. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/8243432/Elevated_glutathione_S_transferase_activity_in_erythrocytes_from_malnourished_children_ L2 - https://medlineplus.gov/childnutrition.html DB - PRIME DP - Unbound Medicine ER -