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A randomized, double-blind, placebo-controlled trial of ketoconazole 2% shampoo versus selenium sulfide 2.5% shampoo in the treatment of moderate to severe dandruff.
J Am Acad Dermatol. 1993 Dec; 29(6):1008-12.JA

Abstract

BACKGROUND

Ketoconazole is highly effective against the yeast Pityrosporum ovale, an organism believed to be involved in the pathogenesis of dandruff.

OBJECTIVE

Our purpose was to evaluate the safety and effectiveness of ketoconazole 2% shampoo versus selenium sulfide 2.5% shampoo and placebo shampoo in patients with moderate to severe dandruff.

METHODS

Features assessed included adherent and loose dandruff scores, presence or absence of irritation, itching, yeast cells, and global improvement rating by the investigator.

RESULTS

A total of 246 patients were included. Mean total adherent dandruff score declined throughout the treatment period with both ketoconazole 2% and selenium sulfide 2.5% shampoos significantly better than placebo at all visits. Ketoconazole was statistically superior to selenium sulfide at day 8 only (p = 0.0026). Both medicated shampoos were significantly better than placebo for reducing irritation and itching. Of the nine adverse experiences reported during the treatment phase, all involved patients treated with selenium sulfide 2.5% shampoo.

CONCLUSION

Both ketoconazole 2% shampoo and selenium sulfide 2.5% shampoo are effective in the treatment of moderate to severe dandruff; however, ketoconazole 2% shampoo appears to be better tolerated.

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Publisher Full Text

Authors+Show Affiliations

Danby FW
Division of Dermatology, Queen's University, Kingston, Ontario, Canada.
Maddin WS
No affiliation info available
Margesson LJ
No affiliation info available
Rosenthal D
No affiliation info available

MeSH

AdolescentAdultAgedChildChild, PreschoolDermatitis, SeborrheicDouble-Blind MethodFemaleHair PreparationsHumansKetoconazoleMaleMiddle AgedScalp DermatosesSelenium CompoundsSeverity of Illness IndexSoapsTime FactorsTreatment Outcome

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8245236

Citation

Danby, F W., et al. "A Randomized, Double-blind, Placebo-controlled Trial of Ketoconazole 2% Shampoo Versus Selenium Sulfide 2.5% Shampoo in the Treatment of Moderate to Severe Dandruff." Journal of the American Academy of Dermatology, vol. 29, no. 6, 1993, pp. 1008-12.
Danby FW, Maddin WS, Margesson LJ, et al. A randomized, double-blind, placebo-controlled trial of ketoconazole 2% shampoo versus selenium sulfide 2.5% shampoo in the treatment of moderate to severe dandruff. J Am Acad Dermatol. 1993;29(6):1008-12.
Danby, F. W., Maddin, W. S., Margesson, L. J., & Rosenthal, D. (1993). A randomized, double-blind, placebo-controlled trial of ketoconazole 2% shampoo versus selenium sulfide 2.5% shampoo in the treatment of moderate to severe dandruff. Journal of the American Academy of Dermatology, 29(6), 1008-12.
Danby FW, et al. A Randomized, Double-blind, Placebo-controlled Trial of Ketoconazole 2% Shampoo Versus Selenium Sulfide 2.5% Shampoo in the Treatment of Moderate to Severe Dandruff. J Am Acad Dermatol. 1993;29(6):1008-12. PubMed PMID: 8245236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized, double-blind, placebo-controlled trial of ketoconazole 2% shampoo versus selenium sulfide 2.5% shampoo in the treatment of moderate to severe dandruff. AU - Danby,F W, AU - Maddin,W S, AU - Margesson,L J, AU - Rosenthal,D, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 1008 EP - 12 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 29 IS - 6 N2 - BACKGROUND: Ketoconazole is highly effective against the yeast Pityrosporum ovale, an organism believed to be involved in the pathogenesis of dandruff. OBJECTIVE: Our purpose was to evaluate the safety and effectiveness of ketoconazole 2% shampoo versus selenium sulfide 2.5% shampoo and placebo shampoo in patients with moderate to severe dandruff. METHODS: Features assessed included adherent and loose dandruff scores, presence or absence of irritation, itching, yeast cells, and global improvement rating by the investigator. RESULTS: A total of 246 patients were included. Mean total adherent dandruff score declined throughout the treatment period with both ketoconazole 2% and selenium sulfide 2.5% shampoos significantly better than placebo at all visits. Ketoconazole was statistically superior to selenium sulfide at day 8 only (p = 0.0026). Both medicated shampoos were significantly better than placebo for reducing irritation and itching. Of the nine adverse experiences reported during the treatment phase, all involved patients treated with selenium sulfide 2.5% shampoo. CONCLUSION: Both ketoconazole 2% shampoo and selenium sulfide 2.5% shampoo are effective in the treatment of moderate to severe dandruff; however, ketoconazole 2% shampoo appears to be better tolerated. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/8245236/A_randomized_double_blind_placebo_controlled_trial_of_ketoconazole_2_shampoo_versus_selenium_sulfide_2_5_shampoo_in_the_treatment_of_moderate_to_severe_dandruff_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0190-9622(93)70282-X DB - PRIME DP - Unbound Medicine ER -