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Quantification analysis of splice signal sequences. Exon skipping in beta-globin gene of thalassemia.

Abstract

Nucleotide sequences of human beta-globin and its mutant genes were analyzed by quantification method. In the mutant, a GT-->AT change occurs at the 5'-splice site of the second intron, causing skipping of the whole second exon during RNA splicing. A mechanism of exon skipping was proposed on the basis of the intensity of 3'-splice signal sequence.

Authors+Show Affiliations

Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8247751

Citation

Iida, Y. "Quantification Analysis of Splice Signal Sequences. Exon Skipping in Beta-globin Gene of Thalassemia." Nucleic Acids Symposium Series, 1993, pp. 161-2.
Iida Y. Quantification analysis of splice signal sequences. Exon skipping in beta-globin gene of thalassemia. Nucleic Acids Symp Ser. 1993.
Iida, Y. (1993). Quantification analysis of splice signal sequences. Exon skipping in beta-globin gene of thalassemia. Nucleic Acids Symposium Series, (29), 161-2.
Iida Y. Quantification Analysis of Splice Signal Sequences. Exon Skipping in Beta-globin Gene of Thalassemia. Nucleic Acids Symp Ser. 1993;(29)161-2. PubMed PMID: 8247751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantification analysis of splice signal sequences. Exon skipping in beta-globin gene of thalassemia. A1 - Iida,Y, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 161 EP - 2 JF - Nucleic acids symposium series JO - Nucleic Acids Symp Ser IS - 29 N2 - Nucleotide sequences of human beta-globin and its mutant genes were analyzed by quantification method. In the mutant, a GT-->AT change occurs at the 5'-splice site of the second intron, causing skipping of the whole second exon during RNA splicing. A mechanism of exon skipping was proposed on the basis of the intensity of 3'-splice signal sequence. SN - 0261-3166 UR - https://www.unboundmedicine.com/medline/citation/8247751/Quantification_analysis_of_splice_signal_sequences__Exon_skipping_in_beta_globin_gene_of_thalassemia_ L2 - http://www.diseaseinfosearch.org/result/814 DB - PRIME DP - Unbound Medicine ER -