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Correlation of histologic grade of breast carcinoma with cytologic features on fine-needle aspiration of the breast.
Mod Pathol. 1993 Sep; 6(5):539-43.MP

Abstract

Histologic grade is an important prognostic factor for breast carcinoma. To determine whether histologic grade could be reproduced on fine-needle aspiration of the breast, we analyzed 50 cases of histologically proven infiltrating ductal carcinomas that had a preoperative fine-needle aspiration. The histologic grade was based on tubule formation, nuclear pleomorphism, and mitotic frequency [a modified Bloom-Richardson (BR) grading system]. Fine-needle aspirations were analyzed for cellularity, cellular arrangements, percentage of single cells, nuclear pleomorphism, mitoses, hyperchromasia, chromatin pattern, nucleoli, and background. The cases in BR Grades 1 and 2 (n = 28) were combined into one category for comparison with those in BR 3 (n = 22). BR 3 was more likely than BR 1 and 2 to be associated with marked nuclear pleomorphism (59 versus 18%, P < 0.05) and vesicular or coarse chromatin (77 versus 43%, P < 0.05). Of the 18 cases that showed both marked nuclear pleomorphism and either coarsely granular or vesicular chromatin on fine-needle aspiration, 13 (72%) were BR Grade 3 on histology. These 13 cases represent 59% of the 22 cases of BR Grade 3 on histology. Aspiration cytology is of some, but limited, use in predicting BR grade. As expected, nuclear features are most easily translated from histology to cytology.

Authors+Show Affiliations

Department of Pathology, Beth Israel Hospital, Boston, Massachusetts.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8248109

Citation

Ducatman, B S., et al. "Correlation of Histologic Grade of Breast Carcinoma With Cytologic Features On Fine-needle Aspiration of the Breast." Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, vol. 6, no. 5, 1993, pp. 539-43.
Ducatman BS, Emery ST, Wang HH. Correlation of histologic grade of breast carcinoma with cytologic features on fine-needle aspiration of the breast. Mod Pathol. 1993;6(5):539-43.
Ducatman, B. S., Emery, S. T., & Wang, H. H. (1993). Correlation of histologic grade of breast carcinoma with cytologic features on fine-needle aspiration of the breast. Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 6(5), 539-43.
Ducatman BS, Emery ST, Wang HH. Correlation of Histologic Grade of Breast Carcinoma With Cytologic Features On Fine-needle Aspiration of the Breast. Mod Pathol. 1993;6(5):539-43. PubMed PMID: 8248109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of histologic grade of breast carcinoma with cytologic features on fine-needle aspiration of the breast. AU - Ducatman,B S, AU - Emery,S T, AU - Wang,H H, PY - 1993/9/1/pubmed PY - 1993/9/1/medline PY - 1993/9/1/entrez SP - 539 EP - 43 JF - Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc JO - Mod Pathol VL - 6 IS - 5 N2 - Histologic grade is an important prognostic factor for breast carcinoma. To determine whether histologic grade could be reproduced on fine-needle aspiration of the breast, we analyzed 50 cases of histologically proven infiltrating ductal carcinomas that had a preoperative fine-needle aspiration. The histologic grade was based on tubule formation, nuclear pleomorphism, and mitotic frequency [a modified Bloom-Richardson (BR) grading system]. Fine-needle aspirations were analyzed for cellularity, cellular arrangements, percentage of single cells, nuclear pleomorphism, mitoses, hyperchromasia, chromatin pattern, nucleoli, and background. The cases in BR Grades 1 and 2 (n = 28) were combined into one category for comparison with those in BR 3 (n = 22). BR 3 was more likely than BR 1 and 2 to be associated with marked nuclear pleomorphism (59 versus 18%, P < 0.05) and vesicular or coarse chromatin (77 versus 43%, P < 0.05). Of the 18 cases that showed both marked nuclear pleomorphism and either coarsely granular or vesicular chromatin on fine-needle aspiration, 13 (72%) were BR Grade 3 on histology. These 13 cases represent 59% of the 22 cases of BR Grade 3 on histology. Aspiration cytology is of some, but limited, use in predicting BR grade. As expected, nuclear features are most easily translated from histology to cytology. SN - 0893-3952 UR - https://www.unboundmedicine.com/medline/citation/8248109/Correlation_of_histologic_grade_of_breast_carcinoma_with_cytologic_features_on_fine_needle_aspiration_of_the_breast_ L2 - https://medlineplus.gov/breastcancer.html DB - PRIME DP - Unbound Medicine ER -