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Regular light-to-moderate intake of alcohol and the risk of ischemic stroke. Is there a beneficial effect?
Stroke 1993; 24(12):1828-32S

Abstract

BACKGROUND AND PURPOSE

To evaluate the association between different patterns of alcohol consumption and the risk of ischemic stroke in young or middle-aged men.

METHODS

One hundred fifty-six patients and 153 control subjects were included in this case-control study. The pattern and the estimated average weekly intake of alcohol were assessed using a structured questionnaire. The pattern of drinking was defined as regular (daily or almost daily) or irregular (up to three times per week), and the weekly amount of consumption was defined as nondrinking, light-to-moderate drinking (up to 150 g/wk), moderate drinking (> 150 to 300 g/wk), and heavy drinking (> 300 g/wk). Multiple stepwise logistic regression models were used, and adjustments were carried out for potential confounders.

RESULTS

Heavy alcohol intake associated with an increased risk of stroke (odds ratio, 4.45; 95% confidence interval, 1.09 to 18.1), whereas the risk tended to be reduced in light-to-moderate drinkers (odds ratio, 0.54; 95% confidence interval, 0.28 to 1.05). Accounting for the pattern of alcohol intake in addition to the average weekly amount in grams, regular light-to-moderate drinking showed a significant inverse association with stroke (odds ratio, 0.12; 95% confidence interval, 0.02 to 0.65), and an irregular pattern of consumption attenuated this association. Based on the same multivariate analyses, other significant independent risk factors for stroke were arterial hypertension, coronary heart disease, and history of snoring, whereas the contributions of age, diabetes mellitus, smoking, and body mass index proved to be nonsignificant.

CONCLUSIONS

Light-to-moderate alcohol intake appears to have an inverse association with the risk of ischemic stroke. The beneficial effect appears to be most prominent if the consumption of alcohol is regular and evenly distributed throughout the week, whereas a sporadic or an occasional pattern of drinking seems to weaken the association. This study also supports the role of heavy drinking as an independent risk factor for ischemic stroke.

Authors+Show Affiliations

Department of Neurology, University of Helsinki, Finland.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8248963

Citation

Palomäki, H, and M Kaste. "Regular Light-to-moderate Intake of Alcohol and the Risk of Ischemic Stroke. Is There a Beneficial Effect?" Stroke, vol. 24, no. 12, 1993, pp. 1828-32.
Palomäki H, Kaste M. Regular light-to-moderate intake of alcohol and the risk of ischemic stroke. Is there a beneficial effect? Stroke. 1993;24(12):1828-32.
Palomäki, H., & Kaste, M. (1993). Regular light-to-moderate intake of alcohol and the risk of ischemic stroke. Is there a beneficial effect? Stroke, 24(12), pp. 1828-32.
Palomäki H, Kaste M. Regular Light-to-moderate Intake of Alcohol and the Risk of Ischemic Stroke. Is There a Beneficial Effect. Stroke. 1993;24(12):1828-32. PubMed PMID: 8248963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regular light-to-moderate intake of alcohol and the risk of ischemic stroke. Is there a beneficial effect? AU - Palomäki,H, AU - Kaste,M, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 1828 EP - 32 JF - Stroke JO - Stroke VL - 24 IS - 12 N2 - BACKGROUND AND PURPOSE: To evaluate the association between different patterns of alcohol consumption and the risk of ischemic stroke in young or middle-aged men. METHODS: One hundred fifty-six patients and 153 control subjects were included in this case-control study. The pattern and the estimated average weekly intake of alcohol were assessed using a structured questionnaire. The pattern of drinking was defined as regular (daily or almost daily) or irregular (up to three times per week), and the weekly amount of consumption was defined as nondrinking, light-to-moderate drinking (up to 150 g/wk), moderate drinking (> 150 to 300 g/wk), and heavy drinking (> 300 g/wk). Multiple stepwise logistic regression models were used, and adjustments were carried out for potential confounders. RESULTS: Heavy alcohol intake associated with an increased risk of stroke (odds ratio, 4.45; 95% confidence interval, 1.09 to 18.1), whereas the risk tended to be reduced in light-to-moderate drinkers (odds ratio, 0.54; 95% confidence interval, 0.28 to 1.05). Accounting for the pattern of alcohol intake in addition to the average weekly amount in grams, regular light-to-moderate drinking showed a significant inverse association with stroke (odds ratio, 0.12; 95% confidence interval, 0.02 to 0.65), and an irregular pattern of consumption attenuated this association. Based on the same multivariate analyses, other significant independent risk factors for stroke were arterial hypertension, coronary heart disease, and history of snoring, whereas the contributions of age, diabetes mellitus, smoking, and body mass index proved to be nonsignificant. CONCLUSIONS: Light-to-moderate alcohol intake appears to have an inverse association with the risk of ischemic stroke. The beneficial effect appears to be most prominent if the consumption of alcohol is regular and evenly distributed throughout the week, whereas a sporadic or an occasional pattern of drinking seems to weaken the association. This study also supports the role of heavy drinking as an independent risk factor for ischemic stroke. SN - 0039-2499 UR - https://www.unboundmedicine.com/medline/citation/8248963/Regular_light_to_moderate_intake_of_alcohol_and_the_risk_of_ischemic_stroke__Is_there_a_beneficial_effect L2 - http://www.ahajournals.org/doi/full/10.1161/01.str.24.12.1828?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -