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Relationship between alpha-aminolevulinic acid dehydratase activity, free erythrocyte protoporphyrin concentration and blood lead in calves from lead contaminated farm.
Vet Hum Toxicol. 1993 Oct; 35(5):393-5.VH

Abstract

In order to investigate useful indicators of lead contamination, 108 Japanese Black calves from a lead-contaminated farm were used. The lead concentrations in blood (Ph-B), delta-aminolevulinic acid dehydratase (ALA-D) activities, and free erythrocyte protoporphyrin (FEP) concentrations were examined. A significant negative correlation was obtained between Pb-B concentrations and ALA-D activities (r = -0.621, p < 0.01). A significant positive correlation was obtained between Ph-B concentrations and FEP concentrations (r = 0.850, p < 0.01). The calves were divided by Pb-B concentrations (micrograms/100 ml) into 5 groups (A = < or = 30, B = 31 approximately 90, C = 91 approximately 150, D = 151 approximately 210, E = > or = 211) to observe the relation of ALA-D activities, FEP concentrations and ALA-D activities in group B (r = -0.706, p < 0.05). A significant positive correlation was obtained between Pb-B concentrations and FEP concentrations in groups A, B and D (A = r = 0.496, p < 0.01; B = r = 0.686, p < 0.01; D = r = 0.529, p < 0.05). These results indicate that FEP concentrations were good indicators of lead contamination.

Authors+Show Affiliations

Department of Veterinary Internal Medicine I, School of Veterinary Medicine, Azabu Univesity, Kanagawa, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8249257

Citation

Wada, Y, et al. "Relationship Between Alpha-aminolevulinic Acid Dehydratase Activity, Free Erythrocyte Protoporphyrin Concentration and Blood Lead in Calves From Lead Contaminated Farm." Veterinary and Human Toxicology, vol. 35, no. 5, 1993, pp. 393-5.
Wada Y, Sato S, Yamaguchi T, et al. Relationship between alpha-aminolevulinic acid dehydratase activity, free erythrocyte protoporphyrin concentration and blood lead in calves from lead contaminated farm. Vet Hum Toxicol. 1993;35(5):393-5.
Wada, Y., Sato, S., Yamaguchi, T., Katsumi, A., & Kobayashi, M. (1993). Relationship between alpha-aminolevulinic acid dehydratase activity, free erythrocyte protoporphyrin concentration and blood lead in calves from lead contaminated farm. Veterinary and Human Toxicology, 35(5), 393-5.
Wada Y, et al. Relationship Between Alpha-aminolevulinic Acid Dehydratase Activity, Free Erythrocyte Protoporphyrin Concentration and Blood Lead in Calves From Lead Contaminated Farm. Vet Hum Toxicol. 1993;35(5):393-5. PubMed PMID: 8249257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between alpha-aminolevulinic acid dehydratase activity, free erythrocyte protoporphyrin concentration and blood lead in calves from lead contaminated farm. AU - Wada,Y, AU - Sato,S, AU - Yamaguchi,T, AU - Katsumi,A, AU - Kobayashi,M, PY - 1993/10/1/pubmed PY - 1993/10/1/medline PY - 1993/10/1/entrez SP - 393 EP - 5 JF - Veterinary and human toxicology JO - Vet Hum Toxicol VL - 35 IS - 5 N2 - In order to investigate useful indicators of lead contamination, 108 Japanese Black calves from a lead-contaminated farm were used. The lead concentrations in blood (Ph-B), delta-aminolevulinic acid dehydratase (ALA-D) activities, and free erythrocyte protoporphyrin (FEP) concentrations were examined. A significant negative correlation was obtained between Pb-B concentrations and ALA-D activities (r = -0.621, p < 0.01). A significant positive correlation was obtained between Ph-B concentrations and FEP concentrations (r = 0.850, p < 0.01). The calves were divided by Pb-B concentrations (micrograms/100 ml) into 5 groups (A = < or = 30, B = 31 approximately 90, C = 91 approximately 150, D = 151 approximately 210, E = > or = 211) to observe the relation of ALA-D activities, FEP concentrations and ALA-D activities in group B (r = -0.706, p < 0.05). A significant positive correlation was obtained between Pb-B concentrations and FEP concentrations in groups A, B and D (A = r = 0.496, p < 0.01; B = r = 0.686, p < 0.01; D = r = 0.529, p < 0.05). These results indicate that FEP concentrations were good indicators of lead contamination. SN - 0145-6296 UR - https://www.unboundmedicine.com/medline/citation/8249257/Relationship_between_alpha_aminolevulinic_acid_dehydratase_activity_free_erythrocyte_protoporphyrin_concentration_and_blood_lead_in_calves_from_lead_contaminated_farm_ L2 - https://medlineplus.gov/leadpoisoning.html DB - PRIME DP - Unbound Medicine ER -