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The chromosomal virulence gene, chvE, of Agrobacterium tumefaciens is regulated by a LysR family member.
J Bacteriol. 1993 Dec; 175(24):7880-6.JB

Abstract

Certain plant phenolic compounds and monosaccharides induce the transcription of virulence (vir) genes of Agrobacterium tumefaciens through the VirA-VirG two-component regulatory system. The product of the chromosomal virulence gene chvE is homologous to galactose-binding protein of Escherichia coli and is required for vir gene induction by sugars. Adjacent to, but divergent in transcription from, chvE is an open reading frame, now termed gbpR (galactose-binding protein regulator), that is homologous to the LysR family of transcriptional regulators. chvE::lacZ expression was induced by L-arabinose, D-galactose, and D-fucose when gbpR was present. In the absence of inducer, GbpR repressed chvE::lacZ expression. In addition, GbpR negatively regulated its own expression.

Authors+Show Affiliations

Department of Microbiology, University of Washington, Seattle 98195.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8253677

Citation

Doty, S L., et al. "The Chromosomal Virulence Gene, chvE, of Agrobacterium Tumefaciens Is Regulated By a LysR Family Member." Journal of Bacteriology, vol. 175, no. 24, 1993, pp. 7880-6.
Doty SL, Chang M, Nester EW. The chromosomal virulence gene, chvE, of Agrobacterium tumefaciens is regulated by a LysR family member. J Bacteriol. 1993;175(24):7880-6.
Doty, S. L., Chang, M., & Nester, E. W. (1993). The chromosomal virulence gene, chvE, of Agrobacterium tumefaciens is regulated by a LysR family member. Journal of Bacteriology, 175(24), 7880-6.
Doty SL, Chang M, Nester EW. The Chromosomal Virulence Gene, chvE, of Agrobacterium Tumefaciens Is Regulated By a LysR Family Member. J Bacteriol. 1993;175(24):7880-6. PubMed PMID: 8253677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The chromosomal virulence gene, chvE, of Agrobacterium tumefaciens is regulated by a LysR family member. AU - Doty,S L, AU - Chang,M, AU - Nester,E W, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 7880 EP - 6 JF - Journal of bacteriology JO - J. Bacteriol. VL - 175 IS - 24 N2 - Certain plant phenolic compounds and monosaccharides induce the transcription of virulence (vir) genes of Agrobacterium tumefaciens through the VirA-VirG two-component regulatory system. The product of the chromosomal virulence gene chvE is homologous to galactose-binding protein of Escherichia coli and is required for vir gene induction by sugars. Adjacent to, but divergent in transcription from, chvE is an open reading frame, now termed gbpR (galactose-binding protein regulator), that is homologous to the LysR family of transcriptional regulators. chvE::lacZ expression was induced by L-arabinose, D-galactose, and D-fucose when gbpR was present. In the absence of inducer, GbpR repressed chvE::lacZ expression. In addition, GbpR negatively regulated its own expression. SN - 0021-9193 UR - https://www.unboundmedicine.com/medline/citation/8253677/The_chromosomal_virulence_gene_chvE_of_Agrobacterium_tumefaciens_is_regulated_by_a_LysR_family_member_ L2 - http://jb.asm.org/cgi/pmidlookup?view=long&pmid=8253677 DB - PRIME DP - Unbound Medicine ER -