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Diaphragmatic fatigue after exercise in healthy human subjects.
Am Rev Respir Dis. 1993 Dec; 148(6 Pt 1):1571-5.AR

Abstract

The purpose of this study was to determine whether diaphragmatic fatigue occurs after high-intensity constant-load whole-body exercise to volitional exhaustion. Ten sedentary subjects with a maximal oxygen uptake of 2.52 +/- 0.47 L/min were studied. Subjects exercised on a bicycle ergometer at 80% of their maximal working capacity until volitional exhaustion. Minute ventilation during the last minute of exercise was 89.9 +/- 13.6 L/min, which represented 50 +/- 6% of the subjects' 12-s maximal voluntary ventilation. During the last minute of exercise, mean inspiratory esophageal pressure was 18.1 +/- 5.3 cm H2O, which represented only 15 +/- 4% of the subjects' maximal static inspiratory pressure. Bilateral transcutaneous supramaximal phrenic nerve stimulation was performed before and 10, 30, 45 and 60 min after exercise. Twitch diaphragmatic pressure (twitch Pdi) was significantly decreased after exercise in seven of the 10 subjects. For the group as a whole, twitch Pdi fell from 28.9 +/- 3.7 cm H2O during control to 23.9 +/- 5.1 cm H2O at 10 min after exercise (p < 0.005). The fall in twitch Pdi was due to a significant decrease in twitch esophageal pressure from 19.6 +/- 4.3 cm H2O during control to 15.5 +/- 4.9 cm H2O (p < 0.001). Twitch gastric pressure was not significantly different: 8.7 +/- 4.0 cm H2O, compared with 9.2 +/- 3.8 cm H2O during control. Twitch Pdi recovered to 93 +/- 7% of control values at 60 min after exercise. The fall in twitch Pdi after exercise indicates that diaphragmatic fatigue can occur following heavy endurance exercise in sedentary healthy persons.

Authors+Show Affiliations

Division of Pulmonary Medicine, State University of New York at Buffalo.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

8256903

Citation

Mador, M J., et al. "Diaphragmatic Fatigue After Exercise in Healthy Human Subjects." The American Review of Respiratory Disease, vol. 148, no. 6 Pt 1, 1993, pp. 1571-5.
Mador MJ, Magalang UJ, Rodis A, et al. Diaphragmatic fatigue after exercise in healthy human subjects. Am Rev Respir Dis. 1993;148(6 Pt 1):1571-5.
Mador, M. J., Magalang, U. J., Rodis, A., & Kufel, T. J. (1993). Diaphragmatic fatigue after exercise in healthy human subjects. The American Review of Respiratory Disease, 148(6 Pt 1), 1571-5.
Mador MJ, et al. Diaphragmatic Fatigue After Exercise in Healthy Human Subjects. Am Rev Respir Dis. 1993;148(6 Pt 1):1571-5. PubMed PMID: 8256903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diaphragmatic fatigue after exercise in healthy human subjects. AU - Mador,M J, AU - Magalang,U J, AU - Rodis,A, AU - Kufel,T J, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 1571 EP - 5 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 148 IS - 6 Pt 1 N2 - The purpose of this study was to determine whether diaphragmatic fatigue occurs after high-intensity constant-load whole-body exercise to volitional exhaustion. Ten sedentary subjects with a maximal oxygen uptake of 2.52 +/- 0.47 L/min were studied. Subjects exercised on a bicycle ergometer at 80% of their maximal working capacity until volitional exhaustion. Minute ventilation during the last minute of exercise was 89.9 +/- 13.6 L/min, which represented 50 +/- 6% of the subjects' 12-s maximal voluntary ventilation. During the last minute of exercise, mean inspiratory esophageal pressure was 18.1 +/- 5.3 cm H2O, which represented only 15 +/- 4% of the subjects' maximal static inspiratory pressure. Bilateral transcutaneous supramaximal phrenic nerve stimulation was performed before and 10, 30, 45 and 60 min after exercise. Twitch diaphragmatic pressure (twitch Pdi) was significantly decreased after exercise in seven of the 10 subjects. For the group as a whole, twitch Pdi fell from 28.9 +/- 3.7 cm H2O during control to 23.9 +/- 5.1 cm H2O at 10 min after exercise (p < 0.005). The fall in twitch Pdi was due to a significant decrease in twitch esophageal pressure from 19.6 +/- 4.3 cm H2O during control to 15.5 +/- 4.9 cm H2O (p < 0.001). Twitch gastric pressure was not significantly different: 8.7 +/- 4.0 cm H2O, compared with 9.2 +/- 3.8 cm H2O during control. Twitch Pdi recovered to 93 +/- 7% of control values at 60 min after exercise. The fall in twitch Pdi after exercise indicates that diaphragmatic fatigue can occur following heavy endurance exercise in sedentary healthy persons. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/8256903/Diaphragmatic_fatigue_after_exercise_in_healthy_human_subjects. L2 - https://www.atsjournals.org/doi/10.1164/ajrccm/148.6_Pt_1.1571?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -