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Effects of treatment on airway dynamics and respiratory muscle strength in Parkinson's disease.
Am Rev Respir Dis. 1993 Dec; 148(6 Pt 1):1576-80.AR

Abstract

To investigate how treatment can affect airway dynamics and respiratory muscle strength in Parkinson's disease (PD), we assessed maximum effort inspiratory and expiratory mouth pressures (MIP and MEP), oscillatory impedance, and maximum expiratory and inspiratory flow-volume curves (MEFV and MIFV) in 10 patients (8 male and 2 female; mean age 51 +/- 5.3 yr, SD) after temporary interruption of antiparkinsonian therapy (off) and during continuous subcutaneous infusion of a direct stimulant of dopamine receptors, apomorphine (on). Treatment improved neurologic scores (off 25 +/- 5, on 9 +/- 5, modified Webster scale, p < 0.001), MEP (off 45 +/- 25, on 63 +/- 29 cm H2O, p = 0.003), and peak inspiratory flow (PIF; off 3.83 +/- 1.6, on 4.37 +/- 1.7 L/s, p = 0.028). Maximum inspiratory pressure was very low off treatment (-25 +/- 16 cm H2O) and improved moderately with apomorphine (-33 +/- 17 cm H2O) (p = 0.064). Total respiratory resistance during tidal breathing was normal in 9 patients both off and on treatment despite, in some cases, dramatic changes in MEFV and MIFV curves. These results suggest that abnormalities of the flow-volume curves may be due to problems in the rapid activation and coordination of contraction of upper airways and chest wall muscles during forced maneuvers, which is improved by apomorphine treatment.

Authors+Show Affiliations

Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, England.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8256904

Citation

de Bruin, P F., et al. "Effects of Treatment On Airway Dynamics and Respiratory Muscle Strength in Parkinson's Disease." The American Review of Respiratory Disease, vol. 148, no. 6 Pt 1, 1993, pp. 1576-80.
de Bruin PF, de Bruin VM, Lees AJ, et al. Effects of treatment on airway dynamics and respiratory muscle strength in Parkinson's disease. Am Rev Respir Dis. 1993;148(6 Pt 1):1576-80.
de Bruin, P. F., de Bruin, V. M., Lees, A. J., & Pride, N. B. (1993). Effects of treatment on airway dynamics and respiratory muscle strength in Parkinson's disease. The American Review of Respiratory Disease, 148(6 Pt 1), 1576-80.
de Bruin PF, et al. Effects of Treatment On Airway Dynamics and Respiratory Muscle Strength in Parkinson's Disease. Am Rev Respir Dis. 1993;148(6 Pt 1):1576-80. PubMed PMID: 8256904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of treatment on airway dynamics and respiratory muscle strength in Parkinson's disease. AU - de Bruin,P F, AU - de Bruin,V M, AU - Lees,A J, AU - Pride,N B, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 1576 EP - 80 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 148 IS - 6 Pt 1 N2 - To investigate how treatment can affect airway dynamics and respiratory muscle strength in Parkinson's disease (PD), we assessed maximum effort inspiratory and expiratory mouth pressures (MIP and MEP), oscillatory impedance, and maximum expiratory and inspiratory flow-volume curves (MEFV and MIFV) in 10 patients (8 male and 2 female; mean age 51 +/- 5.3 yr, SD) after temporary interruption of antiparkinsonian therapy (off) and during continuous subcutaneous infusion of a direct stimulant of dopamine receptors, apomorphine (on). Treatment improved neurologic scores (off 25 +/- 5, on 9 +/- 5, modified Webster scale, p < 0.001), MEP (off 45 +/- 25, on 63 +/- 29 cm H2O, p = 0.003), and peak inspiratory flow (PIF; off 3.83 +/- 1.6, on 4.37 +/- 1.7 L/s, p = 0.028). Maximum inspiratory pressure was very low off treatment (-25 +/- 16 cm H2O) and improved moderately with apomorphine (-33 +/- 17 cm H2O) (p = 0.064). Total respiratory resistance during tidal breathing was normal in 9 patients both off and on treatment despite, in some cases, dramatic changes in MEFV and MIFV curves. These results suggest that abnormalities of the flow-volume curves may be due to problems in the rapid activation and coordination of contraction of upper airways and chest wall muscles during forced maneuvers, which is improved by apomorphine treatment. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/8256904/Effects_of_treatment_on_airway_dynamics_and_respiratory_muscle_strength_in_Parkinson's_disease. L2 - https://www.atsjournals.org/doi/10.1164/ajrccm/148.6_Pt_1.1576?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -