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Corticosteroid withdrawal restores responses to calcium chelators and enhances cholinergic responsiveness.
Am Rev Respir Dis. 1993 Dec; 148(6 Pt 1):1581-5.AR

Abstract

To investigate the importance of the inflammatory response in acute peripheral airway constriction, we measured peripheral airway responses to calcium chelators and acetylcholine in anesthetized Basenji-Greyhound (BG) dogs before, during, and after chronic corticosteroid treatment. A wedged bronchoscope technique was used to measure peripheral airway resistance before and after aerosol challenge with 4% Na2EDTA or acetylcholine (10 micrograms/ml) in contralateral lungs. After the initial measurements, five BG dogs received long-term treatment with methylprednisolone (2 mg/kg/d, subcutaneously), and five dogs were not treated and served as controls. Four weeks of methylprednisolone treatment almost totally abolished responses to Na2EDTA, but responses to acetylcholine did not change significantly. After discontinuing corticosteroid therapy, responses to Na2EDTA returned to levels found before corticosteroid treatment; responses to acetylcholine were significantly enhanced. We conclude that chronic corticosteroid treatment reduces acute response to calcium chelators and that withdrawal of corticosteroid therapy is associated with enhanced cholinergic responsiveness.

Authors+Show Affiliations

Department of Anesthesiology/Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8256905

Citation

Lindeman, K S., and C A. Hirshman. "Corticosteroid Withdrawal Restores Responses to Calcium Chelators and Enhances Cholinergic Responsiveness." The American Review of Respiratory Disease, vol. 148, no. 6 Pt 1, 1993, pp. 1581-5.
Lindeman KS, Hirshman CA. Corticosteroid withdrawal restores responses to calcium chelators and enhances cholinergic responsiveness. Am Rev Respir Dis. 1993;148(6 Pt 1):1581-5.
Lindeman, K. S., & Hirshman, C. A. (1993). Corticosteroid withdrawal restores responses to calcium chelators and enhances cholinergic responsiveness. The American Review of Respiratory Disease, 148(6 Pt 1), 1581-5.
Lindeman KS, Hirshman CA. Corticosteroid Withdrawal Restores Responses to Calcium Chelators and Enhances Cholinergic Responsiveness. Am Rev Respir Dis. 1993;148(6 Pt 1):1581-5. PubMed PMID: 8256905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Corticosteroid withdrawal restores responses to calcium chelators and enhances cholinergic responsiveness. AU - Lindeman,K S, AU - Hirshman,C A, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 1581 EP - 5 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 148 IS - 6 Pt 1 N2 - To investigate the importance of the inflammatory response in acute peripheral airway constriction, we measured peripheral airway responses to calcium chelators and acetylcholine in anesthetized Basenji-Greyhound (BG) dogs before, during, and after chronic corticosteroid treatment. A wedged bronchoscope technique was used to measure peripheral airway resistance before and after aerosol challenge with 4% Na2EDTA or acetylcholine (10 micrograms/ml) in contralateral lungs. After the initial measurements, five BG dogs received long-term treatment with methylprednisolone (2 mg/kg/d, subcutaneously), and five dogs were not treated and served as controls. Four weeks of methylprednisolone treatment almost totally abolished responses to Na2EDTA, but responses to acetylcholine did not change significantly. After discontinuing corticosteroid therapy, responses to Na2EDTA returned to levels found before corticosteroid treatment; responses to acetylcholine were significantly enhanced. We conclude that chronic corticosteroid treatment reduces acute response to calcium chelators and that withdrawal of corticosteroid therapy is associated with enhanced cholinergic responsiveness. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/8256905/Corticosteroid_withdrawal_restores_responses_to_calcium_chelators_and_enhances_cholinergic_responsiveness. L2 - https://www.atsjournals.org/doi/10.1164/ajrccm/148.6_Pt_1.1581?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -