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Comparison of peripheral chemoreceptor responses in monozygotic and dizygotic twin infants.
Am Rev Respir Dis. 1993 Dec; 148(6 Pt 1):1605-9.AR

Abstract

The peripheral chemoresponses of infant twin pairs were determined using a single-breath hyperoxic stimulus. A total of 43 twin pairs of comparable gestation and birth weight were studied during sleep at a mean (SD) age of 8 wk (1.4) while alternately breathing either air or 16% oxygen in nitrogen. Infants responded to a single breath of 100% oxygen by a reduction in ventilation; the mean (SEM) reduction in air was 273 ml/min (10.6) and in 16% oxygen 560 ml/min (18.4). Within-pair variances were compared in 14 monozygotic and 28 dizygotic pairs utilizing combined responses (air + 16% oxygen) computed for measurements made in behavioral quiet sleep and in 9 monozygotic and 20 dizygotic pairs for whom data were complete in polygraphically confirmed quiet sleep. The variance of responses within dizygotic twin pairs was greater than in monozygotic pairs when expressed in ml/min: F ratio 4.11 (p = 0.005) for all data and F ratio 7.67 (p = 0.003) in quiet sleep. Expressed in ml/min/kg the difference was less significant: F ratio 1.83 (p = 0.126) for all data and F ratio 3.46 (p = 0.039) in quiet sleep. Gender, birth weight, and birth order had no effect on these findings. This closer similarity of response in monozygotic twin pairs is explained by proposing a high degree of heritability for the response.

Authors+Show Affiliations

Department of Child Health, University of Leicester, Leicester Royal Infirmary, England.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8256909

Citation

Thomas, D A., et al. "Comparison of Peripheral Chemoreceptor Responses in Monozygotic and Dizygotic Twin Infants." The American Review of Respiratory Disease, vol. 148, no. 6 Pt 1, 1993, pp. 1605-9.
Thomas DA, Swaminathan S, Beardsmore CS, et al. Comparison of peripheral chemoreceptor responses in monozygotic and dizygotic twin infants. Am Rev Respir Dis. 1993;148(6 Pt 1):1605-9.
Thomas, D. A., Swaminathan, S., Beardsmore, C. S., McArdle, E. K., MacFadyen, U. M., Goodenough, P. C., Carpenter, R., & Simpson, H. (1993). Comparison of peripheral chemoreceptor responses in monozygotic and dizygotic twin infants. The American Review of Respiratory Disease, 148(6 Pt 1), 1605-9.
Thomas DA, et al. Comparison of Peripheral Chemoreceptor Responses in Monozygotic and Dizygotic Twin Infants. Am Rev Respir Dis. 1993;148(6 Pt 1):1605-9. PubMed PMID: 8256909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of peripheral chemoreceptor responses in monozygotic and dizygotic twin infants. AU - Thomas,D A, AU - Swaminathan,S, AU - Beardsmore,C S, AU - McArdle,E K, AU - MacFadyen,U M, AU - Goodenough,P C, AU - Carpenter,R, AU - Simpson,H, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 1605 EP - 9 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 148 IS - 6 Pt 1 N2 - The peripheral chemoresponses of infant twin pairs were determined using a single-breath hyperoxic stimulus. A total of 43 twin pairs of comparable gestation and birth weight were studied during sleep at a mean (SD) age of 8 wk (1.4) while alternately breathing either air or 16% oxygen in nitrogen. Infants responded to a single breath of 100% oxygen by a reduction in ventilation; the mean (SEM) reduction in air was 273 ml/min (10.6) and in 16% oxygen 560 ml/min (18.4). Within-pair variances were compared in 14 monozygotic and 28 dizygotic pairs utilizing combined responses (air + 16% oxygen) computed for measurements made in behavioral quiet sleep and in 9 monozygotic and 20 dizygotic pairs for whom data were complete in polygraphically confirmed quiet sleep. The variance of responses within dizygotic twin pairs was greater than in monozygotic pairs when expressed in ml/min: F ratio 4.11 (p = 0.005) for all data and F ratio 7.67 (p = 0.003) in quiet sleep. Expressed in ml/min/kg the difference was less significant: F ratio 1.83 (p = 0.126) for all data and F ratio 3.46 (p = 0.039) in quiet sleep. Gender, birth weight, and birth order had no effect on these findings. This closer similarity of response in monozygotic twin pairs is explained by proposing a high degree of heritability for the response. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/8256909/Comparison_of_peripheral_chemoreceptor_responses_in_monozygotic_and_dizygotic_twin_infants. L2 - https://www.atsjournals.org/doi/10.1164/ajrccm/148.6_Pt_1.1605?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -