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Endothelin-1 in acute lung injury and the adult respiratory distress syndrome.
Am Rev Respir Dis. 1993 Dec; 148(6 Pt 1):1646-50.AR

Abstract

Endothelial damage is a hallmark of acute lung injury. Endothelial mediators may increase pulmonary vascular tone and induce pulmonary arterial muscularization, thereby contributing to the pulmonary hypertension seen with acute lung injury. We measured plasma levels and net pulmonary clearance of endothelin-1, a potent endothelium-derived vasoconstrictor peptide and smooth muscle mitogen, in 26 patients with early acute lung injury, the adult respiratory distress syndrome, and pulmonary hypertension. Nineteen had another data collection at clinical improvement or worsening. Control subjects (n = 25) had no pulmonary hypertension or lung injury. Initial mixed venous and systemic arterial plasma endothelin-1 levels were elevated (4.6 +/- 0.6 SEM and 4.9 +/- 0.6 pg/ml, respectively) as compared with control subjects (0.9 +/- 0.1 and 0.6 +/- 0.1 pg/ml). The systemic arterial/venous endothelin-1 ratio was 1.1 +/- 0.1 (0.7 +/- 0.1 in control subjects), indicating a reduction in normal net pulmonary endothelin-1 clearance. With clinical improvement, as compared with clinical worsening, mean plasma endothelin-1 levels, arterial/venous ratio, and pulmonary arterial pressure fell significantly towards normal. Thus, patients with acute lung injury have marked early increases in circulating plasma endothelin-1 levels, associated with abnormal pulmonary endothelin-1 metabolism. These abnormalities reverse in patients who recover. Through its actions, endothelin-1 could contribute to the pulmonary hypertension seen in acute lung injury.

Authors+Show Affiliations

Division of Cardiology, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8256914

Citation

Langleben, D, et al. "Endothelin-1 in Acute Lung Injury and the Adult Respiratory Distress Syndrome." The American Review of Respiratory Disease, vol. 148, no. 6 Pt 1, 1993, pp. 1646-50.
Langleben D, DeMarchie M, Laporta D, et al. Endothelin-1 in acute lung injury and the adult respiratory distress syndrome. Am Rev Respir Dis. 1993;148(6 Pt 1):1646-50.
Langleben, D., DeMarchie, M., Laporta, D., Spanier, A. H., Schlesinger, R. D., & Stewart, D. J. (1993). Endothelin-1 in acute lung injury and the adult respiratory distress syndrome. The American Review of Respiratory Disease, 148(6 Pt 1), 1646-50.
Langleben D, et al. Endothelin-1 in Acute Lung Injury and the Adult Respiratory Distress Syndrome. Am Rev Respir Dis. 1993;148(6 Pt 1):1646-50. PubMed PMID: 8256914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endothelin-1 in acute lung injury and the adult respiratory distress syndrome. AU - Langleben,D, AU - DeMarchie,M, AU - Laporta,D, AU - Spanier,A H, AU - Schlesinger,R D, AU - Stewart,D J, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - 1646 EP - 50 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 148 IS - 6 Pt 1 N2 - Endothelial damage is a hallmark of acute lung injury. Endothelial mediators may increase pulmonary vascular tone and induce pulmonary arterial muscularization, thereby contributing to the pulmonary hypertension seen with acute lung injury. We measured plasma levels and net pulmonary clearance of endothelin-1, a potent endothelium-derived vasoconstrictor peptide and smooth muscle mitogen, in 26 patients with early acute lung injury, the adult respiratory distress syndrome, and pulmonary hypertension. Nineteen had another data collection at clinical improvement or worsening. Control subjects (n = 25) had no pulmonary hypertension or lung injury. Initial mixed venous and systemic arterial plasma endothelin-1 levels were elevated (4.6 +/- 0.6 SEM and 4.9 +/- 0.6 pg/ml, respectively) as compared with control subjects (0.9 +/- 0.1 and 0.6 +/- 0.1 pg/ml). The systemic arterial/venous endothelin-1 ratio was 1.1 +/- 0.1 (0.7 +/- 0.1 in control subjects), indicating a reduction in normal net pulmonary endothelin-1 clearance. With clinical improvement, as compared with clinical worsening, mean plasma endothelin-1 levels, arterial/venous ratio, and pulmonary arterial pressure fell significantly towards normal. Thus, patients with acute lung injury have marked early increases in circulating plasma endothelin-1 levels, associated with abnormal pulmonary endothelin-1 metabolism. These abnormalities reverse in patients who recover. Through its actions, endothelin-1 could contribute to the pulmonary hypertension seen in acute lung injury. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/8256914/Endothelin-1_in_acute_lung_injury_and_the_adult_respiratory_distress_syndrome. L2 - https://www.atsjournals.org/doi/10.1164/ajrccm/148.6_Pt_1.1646?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -