Tags

Type your tag names separated by a space and hit enter

Adhesion molecules in the lung. An overview.
Am Rev Respir Dis. 1993 Dec; 148(6 Pt 2):S31-7.AR

Abstract

Several distinct cell adhesion molecule families have recently been identified and found to be important in the inflammatory response and for epithelial and endothelial homeostasis. The integrin family of adhesion molecules functions in both cell-matrix and cell-cell interactions, whereas the cadherins serve as important cell-cell receptors for maintenance of epithelial integrity. The leukocyte integrins, selectins, members of the immunoglobulin supergene family, and specific carbohydrates mediate adhesive interactions between leukocytes and endothelial cells. The mechanisms of leukocyte-epithelial adhesion are less well understood, but integrins and members of the immunoglobulin supergene family are also involved. The role of these molecules in pulmonary structure and inflammation is currently being actively explored. Further knowledge of these interactions, and the interplay of adhesion molecules, cytokines, and chemoattractants is likely to lead to novel therapeutic modalities in inflammatory diseases of the airway and lung parenchyma. In this overview, the families of adhesion molecules will be summarized, and their relevance for pulmonary structure and inflammation will be discussed.

Authors+Show Affiliations

Department of Medicine, University of Pennsylvania, Philadelphia.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

8256922

Citation

Pilewski, J M., and S M. Albelda. "Adhesion Molecules in the Lung. an Overview." The American Review of Respiratory Disease, vol. 148, no. 6 Pt 2, 1993, pp. S31-7.
Pilewski JM, Albelda SM. Adhesion molecules in the lung. An overview. Am Rev Respir Dis. 1993;148(6 Pt 2):S31-7.
Pilewski, J. M., & Albelda, S. M. (1993). Adhesion molecules in the lung. An overview. The American Review of Respiratory Disease, 148(6 Pt 2), S31-7.
Pilewski JM, Albelda SM. Adhesion Molecules in the Lung. an Overview. Am Rev Respir Dis. 1993;148(6 Pt 2):S31-7. PubMed PMID: 8256922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adhesion molecules in the lung. An overview. AU - Pilewski,J M, AU - Albelda,S M, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - S31 EP - 7 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 148 IS - 6 Pt 2 N2 - Several distinct cell adhesion molecule families have recently been identified and found to be important in the inflammatory response and for epithelial and endothelial homeostasis. The integrin family of adhesion molecules functions in both cell-matrix and cell-cell interactions, whereas the cadherins serve as important cell-cell receptors for maintenance of epithelial integrity. The leukocyte integrins, selectins, members of the immunoglobulin supergene family, and specific carbohydrates mediate adhesive interactions between leukocytes and endothelial cells. The mechanisms of leukocyte-epithelial adhesion are less well understood, but integrins and members of the immunoglobulin supergene family are also involved. The role of these molecules in pulmonary structure and inflammation is currently being actively explored. Further knowledge of these interactions, and the interplay of adhesion molecules, cytokines, and chemoattractants is likely to lead to novel therapeutic modalities in inflammatory diseases of the airway and lung parenchyma. In this overview, the families of adhesion molecules will be summarized, and their relevance for pulmonary structure and inflammation will be discussed. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/8256922/Adhesion_molecules_in_the_lung._An_overview. L2 - https://www.atsjournals.org/doi/10.1164/ajrccm/148.6_Pt_2.S31?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -