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Identification and characterization of novel airway epithelial integrins.
Am Rev Respir Dis. 1993 Dec; 148(6 Pt 2):S38-42.AR

Abstract

Integrins are heterodimeric glycoproteins that mediate cell-to-matrix and some cell-to-cell interactions. Recent evidence underscores the important roles of these receptors in signaling machines that transduce positional information into complex changes in cell behavior. As such, integrins have been shown to play critical roles in cell growth, differentiation, and migration. Most cells express multiple members of this family, but the integrin repertoire of any given cell appears to be highly tissue- and cell-type-specific. We have used the homology-based polymerase chain reaction to identify known and novel integrin subunits in airway epithelial cells. With this technique we have identified three novel integrin subunits that participate in the formation of at least four novel integrin heterodimers. The best characterized of these, alpha v beta 6, is a receptor for the extracellular matrix protein fibronectin, and appears to be expressed only in terminally differentiated mucosal epithelial cells. The novel alpha subunit, alpha 9, forms a heterodimer with the known beta subunit, beta 1, in some epithelial cell lines. Elucidatation of the specific roles these receptors play in airway health and disease will likely provide unique insights into both the biology of integrins and the biology of the airway epithelium.

Authors+Show Affiliations

Lung Biology Center, University of California at San Francisco.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8256923

Citation

Sheppard, D. "Identification and Characterization of Novel Airway Epithelial Integrins." The American Review of Respiratory Disease, vol. 148, no. 6 Pt 2, 1993, pp. S38-42.
Sheppard D. Identification and characterization of novel airway epithelial integrins. Am Rev Respir Dis. 1993;148(6 Pt 2):S38-42.
Sheppard, D. (1993). Identification and characterization of novel airway epithelial integrins. The American Review of Respiratory Disease, 148(6 Pt 2), S38-42.
Sheppard D. Identification and Characterization of Novel Airway Epithelial Integrins. Am Rev Respir Dis. 1993;148(6 Pt 2):S38-42. PubMed PMID: 8256923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification and characterization of novel airway epithelial integrins. A1 - Sheppard,D, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - S38 EP - 42 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 148 IS - 6 Pt 2 N2 - Integrins are heterodimeric glycoproteins that mediate cell-to-matrix and some cell-to-cell interactions. Recent evidence underscores the important roles of these receptors in signaling machines that transduce positional information into complex changes in cell behavior. As such, integrins have been shown to play critical roles in cell growth, differentiation, and migration. Most cells express multiple members of this family, but the integrin repertoire of any given cell appears to be highly tissue- and cell-type-specific. We have used the homology-based polymerase chain reaction to identify known and novel integrin subunits in airway epithelial cells. With this technique we have identified three novel integrin subunits that participate in the formation of at least four novel integrin heterodimers. The best characterized of these, alpha v beta 6, is a receptor for the extracellular matrix protein fibronectin, and appears to be expressed only in terminally differentiated mucosal epithelial cells. The novel alpha subunit, alpha 9, forms a heterodimer with the known beta subunit, beta 1, in some epithelial cell lines. Elucidatation of the specific roles these receptors play in airway health and disease will likely provide unique insights into both the biology of integrins and the biology of the airway epithelium. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/8256923/Identification_and_characterization_of_novel_airway_epithelial_integrins. L2 - https://www.atsjournals.org/doi/10.1164/ajrccm/148.6_Pt_2.S38?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -