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Mechanisms of neutrophil and eosinophil accumulation in vivo.
Am Rev Respir Dis. 1993 Dec; 148(6 Pt 2):S60-4.AR

Abstract

The accumulation of leukocytes into tissues is a characteristic feature of inflammatory reactions. This process is triggered by chemical signals generated in a tissue in response to an inflammatory stimulus e.g., invading microbes, other foreign organisms, allergens, or damaged tissue cells. The mechanisms involved in neutrophil and eosinophil accumulation in vivo are complex and dependent on an initial interaction between the leukocytes and the microvascular endothelial cells. This response is regulated by the coordinated expression and/or activation of leukocyte and endothelial cell adhesion molecules. The precise mechanisms that control the selective accumulation of eosinophils, as opposed to neutrophils, in certain inflammatory reactions (e.g., in IgE-mediated allergic reactions) remain unclear. This may be explained partly by the generation of eosinophil-specific inflammatory mediators and activation of selective adhesion pathways such as the VLA-4/VCAM-1 interaction. Although the neutrophil and eosinophil have distinct roles in host defense, they have been implicated in the pathogenesis of a number of inflammatory disorders. Thus, a better understanding of the events mediating and regulating neutrophil and eosinophil accumulation in vivo will be of considerable value in the development of therapeutic strategies for inflammatory disease states.

Authors+Show Affiliations

Department of Applied Pharmacology, National Heart & Lung Institute, London, United Kingdom.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

8256924

Citation

Nourshargh, S. "Mechanisms of Neutrophil and Eosinophil Accumulation in Vivo." The American Review of Respiratory Disease, vol. 148, no. 6 Pt 2, 1993, pp. S60-4.
Nourshargh S. Mechanisms of neutrophil and eosinophil accumulation in vivo. Am Rev Respir Dis. 1993;148(6 Pt 2):S60-4.
Nourshargh, S. (1993). Mechanisms of neutrophil and eosinophil accumulation in vivo. The American Review of Respiratory Disease, 148(6 Pt 2), S60-4.
Nourshargh S. Mechanisms of Neutrophil and Eosinophil Accumulation in Vivo. Am Rev Respir Dis. 1993;148(6 Pt 2):S60-4. PubMed PMID: 8256924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanisms of neutrophil and eosinophil accumulation in vivo. A1 - Nourshargh,S, PY - 1993/12/1/pubmed PY - 1993/12/1/medline PY - 1993/12/1/entrez SP - S60 EP - 4 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 148 IS - 6 Pt 2 N2 - The accumulation of leukocytes into tissues is a characteristic feature of inflammatory reactions. This process is triggered by chemical signals generated in a tissue in response to an inflammatory stimulus e.g., invading microbes, other foreign organisms, allergens, or damaged tissue cells. The mechanisms involved in neutrophil and eosinophil accumulation in vivo are complex and dependent on an initial interaction between the leukocytes and the microvascular endothelial cells. This response is regulated by the coordinated expression and/or activation of leukocyte and endothelial cell adhesion molecules. The precise mechanisms that control the selective accumulation of eosinophils, as opposed to neutrophils, in certain inflammatory reactions (e.g., in IgE-mediated allergic reactions) remain unclear. This may be explained partly by the generation of eosinophil-specific inflammatory mediators and activation of selective adhesion pathways such as the VLA-4/VCAM-1 interaction. Although the neutrophil and eosinophil have distinct roles in host defense, they have been implicated in the pathogenesis of a number of inflammatory disorders. Thus, a better understanding of the events mediating and regulating neutrophil and eosinophil accumulation in vivo will be of considerable value in the development of therapeutic strategies for inflammatory disease states. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/8256924/Mechanisms_of_neutrophil_and_eosinophil_accumulation_in_vivo. L2 - https://www.atsjournals.org/doi/10.1164/ajrccm/148.6_Pt_2.S60?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -